PMID: 16641533Apr 28, 2006Paper

The treatment of refractory pneumothorax in diffuse panbronchiolitis by intravenous administration of coagulation factor XIII concentrate

Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
Akira MurataShoji Kudoh

Abstract

This case report presents a patient with advanced diffuse panbronchiolitis accompanied by chronic respiratory failure, marked cachexia, and refractory spontaneous pneumothorax. Because instillation of a pleurodesis agent and thoracoscopy were considered highly risky and invasive, we instead treated the patient with intravenous administration of a coagulation factor XIII concentrate, and the pneumothorax resolved. This case suggests refractory pneumothorax in a restrictive ventilatory disorder can be effectively treated with noninvasive intravenous administration of coagulation factor XIII concentrate.

References

Dec 8, 1972·Annals of the New York Academy of Sciences·E Ikkala
Feb 18, 1995·Lancet·R LorenzM Classen
Aug 10, 2005·Seminars in Respiratory and Critical Care Medicine·Shoji Kudoh, Naoto Keicho

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