The treatment of severe action myoclonus

Brain : a Journal of Neurology
J A ObesoC D Marsden

Abstract

Ten patients with severe disabling myoclonus were treated with clonazepam, sodium valproate, primidone and piracetam alone, or in different combinations. Electrophysiological assessment indicated a cortical origin for the myoclonus in every case. Considerable improvement of myoclonus was achieved with combinations of these drugs in all patients, but this was not possible with monotherapy. In one patient two drugs were necessary (clonazepam and piracetam); in the others more than two drugs were required. The combination of sodium valproate, clonazepam and primidone (3 patients), or piracetam, clonazepam and primidone (3 patients), or the four drugs together (3 patients) was necessary to provide substantial relief of myoclonus. Such polytherapy generally was tolerated well. The benefits of treatment continued for more than 1 year in all cases, although progressive underlying pathology often caused other increasing disability.

Citations

Jan 14, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·W G OndoW D Le
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Robert SchauerMarkus Kofler
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·J ArtiedaJ A Obeso
Jan 1, 1992·Movement Disorders : Official Journal of the Movement Disorder Society·J ArtiedaJ A Obeso
Jan 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·P BrownC D Marsden
Sep 26, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A GambardellaA Quattrone
Oct 1, 1991·Electroencephalography and Clinical Neurophysiology·E KuneschH J Freund
May 1, 1995·Brain & Development·S Sugama, K Kusano
Jul 1, 1996·Mayo Clinic Proceedings·J N Caviness
Sep 5, 2001·Neurologic Clinics·K Blindauer
Jan 30, 2002·Pediatric Neurology·Kuriko Kagitani-ShimonoShintaro Okada
Jan 22, 2002·Clinical Neuropharmacology·M R PranzatelliA Wheeler
Jun 6, 2006·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Manuel AlegreJulio Artieda
Oct 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·C S Lu, N S Chu
Apr 13, 2002·Neurosurgery·Joachim K Krauss, Joseph Jankovic
Jul 25, 2012·Neuroscience Research·R Lalonde, C Strazielle
Oct 3, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Raoul SutterPeter Fuhr
Jul 12, 2005·CNS Drug Reviews·Bengt Winblad
Aug 2, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Jorge GuridiJose A Obeso
May 28, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Petra KatschnigKailash P Bhatia
Aug 7, 2013·Parkinsonism & Related Disorders·Carmen Gasca-SalasPau Pastor
Nov 16, 2014·Current Neurology and Neuroscience Reports·Kelly Mills, Zoltan Mari
Sep 24, 2004·Lancet Neurology·John N Caviness, Peter Brown
Jan 10, 2017·Expert Opinion on Pharmacotherapy·Pasquale Striano, Vincenzo Belcastro
Apr 28, 2016·Clinical EEG and Neuroscience·Brin FreundPeter W Kaplan
Mar 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·K J WerhahnC D Marsden
Mar 16, 2019·Expert Review of Neurotherapeutics·Christine M Stahl, Steven J Frucht
Sep 17, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·John N Caviness
Jul 30, 2019·Continuum : Lifelong Learning in Neurology·John N Caviness
Feb 28, 2020·Journal of Palliative Medicine·Jerry A McQuainDeborah A Morris
Apr 15, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jean Rivest
Jan 1, 1993·Epilepsia·S F BerkovicF Andermann
Feb 9, 2017·Current Neurology and Neuroscience Reports·Giovanni Cossu, Carlo Colosimo
Sep 11, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ashley B Pena, John N Caviness
Sep 19, 2003·Journal of Child Neurology·Terence S Edgar
Mar 24, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S FranceschettiF Panzica

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