The treatment of traumatic brain injury with velcade.

Journal of Neurotrauma
Changsheng QuMichael Chopp

Abstract

Traumatic brain injury (TBI) elicits a strong inflammatory response that contributes to the acute pathological processes seen following TBI, including cerebral edema and disruption of the blood-brain barrier (BBB), in addition to longer-term neurological damage and cognitive impairment. Proteasome inhibitors reduce vascular thrombotic and inflammatory events and consequently protect vascular function. In the present study we evaluated the neuroprotective effect of Velcade (bortezomib), a potent and selective inhibitor of proteasomes, which is in clinical use for the treatment of multiple myeloma. When administered within 2 h after TBI onset, Velcade reduced inflammatory responses, lesion volume, and neurological functional deficits, and enhanced neuronal survival. Western blot and ELISA showed that Velcade decreased the expression of NF-κB. These results suggest that in the experimental setting, Velcade is an effective neuroprotective agent for the treatment of TBI.

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Citations

Jun 5, 2013·Cell Biology and Toxicology·Panagiotis J VlachostergiosChristos N Papandreou
Mar 2, 2013·Journal of Neuroinflammation·Susanne M SchwarzmaierNikolaus Plesnila
Jan 29, 2013·The Journal of Trauma and Acute Care Surgery·Harold H BachMatthias Majetschak
Aug 26, 2017·Scientific Reports·Kasey E MoritzBarrington G Burnett
Jul 25, 2021·Trends in Neurosciences·Janani Saikumar, Nancy M Bonini

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
protein assay
electrophoresis

Software Mentioned

Velcade
PathScan
Scion
SUMMIT

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