The treatment of urinary tract infections and use of ciprofloxacin extended release

Expert Opinion on Investigational Drugs
Adam D Hickerson, Culley Carson


Urinary tract infections (UTIs) are one of the most common reasons people seek medical attention. There are > 50% of women who will have at least one UTI during their lifetime and most of these will require a physician visit and antibiotic treatment. The high prevalence continues to the in-patient setting where genitourinary infections are the most common nosocomial infection. The efficient diagnosis and effective treatment of UTIs is a major healthcare concern. Factors such as economic efficiency and emerging resistance are increasingly becoming more important considerations in providing patient care. In out-patient uncomplicated UTIs, Escherichia coli has been implicated in < or = 75-90% of cases. Although the prevalence in the in-patient setting decreases, E. coli is still the most common bacteria identified and present in 21-54% of urinary isolates. Trimethoprim-sulfamethoxazole has been the preferred first-line agent for uncomplicated out-patient UTIs where local resistance is < 10 - 20%. In recent years, resistance has superseded this threshold in most regions of the US and Europe. In these areas with increased resistance, fluoroquinolones have become a common first-line agent. Ciprofloxacin has been one of the most widel...Continue Reading


Oct 1, 1991·Annals of Emergency Medicine·J M SpiveyD E Nix
Mar 1, 1990·Diagnostic Microbiology and Infectious Disease·T Bergan
Nov 1, 1985·American Journal of Public Health·B Foxman, R R Frerichs
Feb 1, 1972·Postgraduate Medical Journal·C E Mabeck
May 1, 1984·The Journal of Antimicrobial Chemotherapy·W Brumfitt, J M Hamilton-Miller
Oct 6, 1997·Infectious Disease Clinics of North America·C Svanborg, G Godaly
Oct 6, 1997·Infectious Disease Clinics of North America·A Stapleton, W E Stamm
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W WarrenW E Stamm
Feb 24, 2001·International Journal of Antimicrobial Agents·P C Appelbaum, P A Hunter
Dec 26, 2001·European Urology·K G NaberUNKNOWN Urinary Tract Infection (UTI) Working Group of the Health Care Office (HCO) of the European Association of Urology (EAU)
Apr 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R RazUNKNOWN Israeli Urinary Tract Infection Group
Jun 28, 2002·Scandinavian Journal of Primary Health Care·Thierry C M ChristiaensAnders Baerheim
Jul 13, 2002·The American Journal of Medicine·Allan Ronald
May 27, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yasmin Khaliq, George G Zhanel
Sep 25, 2003·Antimicrobial Agents and Chemotherapy·Patricia Komp LindgrenDiarmaid Hughes
Oct 7, 2003·International Journal of Antimicrobial Agents·Thomas M Hooton
Dec 10, 2003·Journal of Medical Microbiology·Feng-Jui ChenHsiu-Jung Lo
Dec 23, 2003·The Pediatric Infectious Disease Journal·Martin A KoylePeter D Furness
Jan 24, 2004·The European Respiratory Journal·D SteigerJ D Leuppi
Mar 24, 2004·International Journal of Antimicrobial Agents·David A TalanDavid Elkharrat
Mar 31, 2004·The Medical Clinics of North America·Sean P McLaughlin, Culley C Carson
May 20, 2004·The Annals of Pharmacotherapy·Karla M KillgoreB Joseph Guglielmo
May 25, 2004·Antimicrobial Agents and Chemotherapy·Alison K MeagherJerome J Schentag
Sep 15, 2004·International Journal of Antimicrobial Agents·Tetsuro Muratani, Tetsuro Matsumoto
Jan 22, 2005·Current Allergy and Asthma Reports·Kathrin Scherer, Andreas J Bircher
Feb 18, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J-I AlósJ Perianes
Feb 25, 2005·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kiyohito IshikawaKiyotaka Hoshinaga
Mar 12, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F Van BambekeP M Tulkens
Mar 12, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A MahamatA Sotto
Apr 15, 2005·Emerging Infectious Diseases·Jesús OteoUNKNOWN Spanish members of EARSS
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Manu Prabhakar, Andrew D Krahn

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Jun 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·B San MartinF Andre
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