The treatment with pasireotide in Cushing's disease: effects of long-term treatment on tumor mass in the experience of a single center

Endocrine
Chiara SimeoliR Pivonello

Abstract

Pasireotide is the first medical therapy officially approved for the treatment of adult patients with Cushing's disease (CD) who experienced a failure of pituitary surgery or are not candidates for surgery and require medical therapeutic intervention. The current study aimed at investigating the effects of long-term treatment with pasireotide (up to 24 months) on tumor mass in a group of patients with CD, participating to a phase III study. Fourteen CD patients entered the phase III clinical trial CSOM230B2305 at Naples Center, and eight (seven women, one man, aged 38.9 ± 17.6 years), including seven with a microadenoma and one with a macroadenoma, received treatment with pasireotide at the dose of 600-1200 µg bid for at least 6 months, and were considered for the analysis of the study. These eight patients were subjected to the evaluation of pituitary tumor volume by pituitary MRI, together with the evaluation of urinary cortisol levels, at baseline and every 6 months for the entire period of treatment. Pasireotide treatment induced full disease control in 37.5 % and partial disease control in 37.5 % after 6 months, whereas full and partial disease control after 12 months was obtained in 28.6 % and in 57.1 % of patients, respe...Continue Reading

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Citations

Feb 3, 2016·Drugs·Krystallenia I Alexandraki, Ashley B Grossman
Jul 29, 2015·Endocrine·Mirsala SolakDarko Kastelan
Oct 21, 2016·Expert Opinion on Therapeutic Patents·Li MaQingzhong Hu
Jun 9, 2018·Frontiers in Endocrinology·Mariana FuertesEduardo Arzt
Jul 14, 2017·Clinical Diabetes and Endocrinology·Daniel Cuevas-RamosMaria Fleseriu
Jan 1, 2016·Expert Review of Endocrinology & Metabolism·Krystallenia I Alexandraki, Ashley B Grossman
May 17, 2018·Frontiers in Endocrinology·Fabienne LangloisMaria Fleseriu
Dec 29, 2020·Frontiers in Endocrinology·Rosario PivonelloAnnamaria Colao
Oct 5, 2021·Frontiers in Endocrinology·Julia Simões Corrêa GalendiVania Dos Santos Nunes Nogueira

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