PMID: 2124336Aug 14, 1990Paper

The TRH analogue MK-771, increases acetylcholine release in hippocampus but not striatum of the conscious rat

Neuroscience Letters
P H HutsonD N Middlemiss

Abstract

Hippocampal and striatal extracellular acetylcholine levels were monitored in conscious rats using the technique of intracerebral dialysis. Scopolamine (1 mg/kg, i.p.) resulted in a marked increase of acetylcholine release in both regions whereas the thyrotropin-releasing hormone (TRH) analogue MK-771 (2.5, 5 and 10 mg/kg, i.p.) only increased acetylcholine release in the hippocampus. The relevance of the present findings in relation to the known cognitive enhancing effects of TRH analogues is discussed.

References

Dec 19, 1989·European Journal of Pharmacology·S B FreedmanS Patel
Jul 15, 1983·European Journal of Pharmacology·M MarchiM Raiteri
Jul 1, 1980·Pharmacology, Biochemistry, and Behavior·S MoraL Fieschi

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Citations

Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S A StwertkaA G Verderese
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·A KhanM H Mirolo
Jul 1, 1997·Experimental Gerontology·G W BennettK C Fone
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino

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