PMID: 5911534Mar 1, 1966

The tricarboxylic acid cycle and glycolysis in relation to ion transport by the ciliary body

The Biochemical Journal
M V Riley

Abstract

1. The respiration and aerobic glycolysis of pig ciliary processes in oxygenated phosphate and bicarbonate buffers have been investigated. 2. Significant amounts of lactic acid are produced only in the presence of added glucose, but this does not change the endogenous respiration rate. 3. Succinate and citrate increase the oxygen uptake considerably, but pyruvate has almost no effect; oxaloacetate and fumarate stimulate slightly in the presence of glucose. Aspartate and fumarate together stimulate pyruvate utilization and are oxidized as fast as citrate. 4. Ouabain inhibits the oxidation of glucose and other substrates by limiting the ADP supply from the sodium transport system. Cyanide and azide inhibit respiration and stimulate glycolysis. 5. The transport mechanism depends largely on ATP from oxidative phosphorylation and regulates the rate of respiration and glycolysis by controlling ADP production from the Na(+)-K(+)-activated adenosine triphosphatase.

Citations

Feb 1, 1984·Experimental Eye Research·T KrupinS M Podos
Jun 1, 1980·Experimental Eye Research·L E Stramm, E L Pautler
Aug 10, 1973·Experimental Eye Research·K Green, J E Pederson
Oct 1, 2004·American Journal of Physiology. Cell Physiology·Glyn ChidlowNeville N Osborne

Related Concepts

Adenosine Triphosphate, Chromium Ammonium Salt
Aspartic Acid, Magnesium-Potassium (2:1:2) Salt
Azides
Ciliary Body
Citrates
Citric Acid Cycle
Isocyanides
Fumaric Acid Esters
Glucose, (beta-D)-Isomer
Glycolysis

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