The Triggering Receptor Expressed on Myeloid cells-1: A new player during acute myocardial infarction.

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Lemarié JérémieGibot Sébastien

Abstract

Following myocardial ischemia, an intense activation of the immune system occurs that leads to inflammatory cytokines and chemokines production and to the recruitment of neutrophils and mononuclear cells in the infarcted area. Although pro-inflammatory signals initiate the cellular events necessary for scar formation, excessive and prolonged inflammation promotes deleterious cardiac remodeling and dysfunction. The triggering receptor expressed on myeloid cells-1 (TREM-1) is a highly conserved immune-receptor expressed by neutrophils and monocytes that acts as an amplifier of the innate immune response. Blockade of TREM-1 activation protects from hyper-responsiveness and death during severe infections. Here we review the role of TREM-1 in orchestrating the inflammatory response that follows MI. TREM-1 deletion (Trem-1-/-) or modulation by the use of a short inhibitory peptide (LR12) dampens myocardial inflammation, limits leukocyte recruitment, and improves heart function and survival in mice or pigs. Moreover, the soluble form of TREM-1 (sTREM-1) is found in the plasma of patients suffering from an acute MI and its concentration is an independent predictor of death. This suggests that TREM-1 may constitute a new therapeutic tar...Continue Reading

References

Mar 30, 2002·Molecular Immunology·Marie-Claude GingrasJudith F Margolin
Sep 11, 2004·Circulation Research·Samantha A TavenerPaul Kubes
Sep 9, 2006·The Journal of Infectious Diseases·Sébastien GibotBruno Lévy
Apr 25, 2007·Blood·Philipp HaselmayerMarkus P Radsak
Nov 17, 2007·The Journal of Infectious Diseases·W Joost WiersingaTom van der Poll
Dec 20, 2007·Critical Care Medicine·Sébastien GibotBruno Levy
Jan 15, 2008·Immunology Letters·Anja S Tessarz, Adelheid Cerwenka
Feb 24, 2009·Current Opinion in Immunology·Jill W Ford, Daniel W McVicar
Sep 30, 2009·Journal of Hepato-biliary-pancreatic Sciences·Keiko KameiHitoshi Shiozaki
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Oct 7, 2011·International Journal of Inflammation·Yan Feng, Wei Chao
Apr 24, 2012·Heart·Michel HanssenUNKNOWN FAST-MI 2010 Investigators
Dec 1, 2012·Critical Care : the Official Journal of the Critical Care Forum·Youping WuXiaoming Deng
Dec 18, 2012·The Journal of Clinical Investigation·Julia Klesney-TaitMarco Colonna
Jan 12, 2013·Science·Filip K Swirski, Matthias Nahrendorf
Mar 29, 2013·European Heart Journal·Georg M FröhlichDerek J Hausenloy
Sep 7, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Adam J Perricone, Richard S Vander Heide
Apr 5, 2015·Circulation Research·Amir BoufenzerSébastien Gibot

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Citations

Jun 10, 2018·British Journal of Clinical Pharmacology·Valerie CuvierMargarita Salcedo-Magguilli
Nov 26, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jason O BrantMalcolm Maden
Sep 13, 2018·Journal of Cardiovascular Development and Disease·Kouassi T KouassiGopal P Jadhav
Mar 8, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Antoine KimmounUNKNOWN CardShock Investigators and the GREAT network

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