Apr 19, 2019

The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore

The Journal of Frailty & Aging
C GussagoB Arosio

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disorder, strongly related with age. It has been reported that genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2), a cell-surface receptor expressed in microglial cells, greatly increase the risk of AD, thus suggesting an involvement of the microglia in the AD pathogenesis. The aim of this report is to provide an overview of the TREM2 and of its possible implication in the pathogenesis of AD.

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Mentioned in this Paper

Pathogenesis
TREM2 gene
Myeloid Cells
Alzheimer's Disease
TREM2
Cell Surface
TREM2 protein, human
Microglia
Receptor
Neurodegenerative Disorders

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