The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale

American Heart Journal
Michael A PortmanAnthony Azakie

Abstract

Cardiopulmonary bypass induces marked and persistent depression of circulating thyroid hormones in infants and children, possibly contributing to postoperative morbidity. Clinical studies have evaluated parenteral triiodothyronine supplementation after cardiopulmonary bypass in children. However, these investigations had relatively small subject numbers as well as age and diagnosis heterogeneity, thereby limiting ability to determine clinical effect. A double-blind, randomized, placebo-controlled trial is needed to define clinical safety and efficacy of triiodothyronine supplementation in infants. The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study is a multicenter, randomized, clinical trial designed to determine safety and efficacy of triiodothyronine supplementation in children <2 years of age undergoing surgical procedures for congenital heart disease. Duration of mechanical ventilation after completion of cardiopulmonary bypass is the primary clinical outcome parameter with multiple secondary clinical and hemodynamic parameters. Nearly 200 patients will be randomly assigned to receive either triiodothyronine or placebo. Patient assignment will be performed using a stratified block ...Continue Reading

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Citations

Sep 26, 2009·Endocrine·Seth D Marks
May 19, 2009·Current Opinion in Pediatrics·Judy L Shih, Michael S D Agus
Jul 12, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Eva M MarwaliNikolaus A Haas
May 25, 2006·Critical Care : the Official Journal of the Critical Care Forum·Nikolaus A HaasDeniz Kececioglu
Oct 29, 2010·Journal of Perinatal Medicine·Gustavo S GoldsmitSonia Iorcansky
Nov 15, 2008·Seminars in Perinatology·Sergio G Golombek
Nov 15, 2008·Seminars in Perinatology·Michael A Portman
Jan 26, 2006·The Journal of Thoracic and Cardiovascular Surgery·Nikolaus A Haas, Christoph K Camphausen
Jul 22, 2004·The Cochrane Database of Systematic Reviews·S DimmickT Randell

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