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The trithorax-group and polycomb-group chromatin modifiers: implications for disease

Current Opinion in Genetics & Development

Jun 1, 1999

Maarten Van Lohuizen

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Abstract

The chromatin structure associated transcriptional memory function by Polycomb-group and trithorax-group protein complexes integrate normal development with control of cellular proliferation. This is illustrated by recent mechanistic insights that link Polycomb repression with histone d...read more

Mentioned in this Paper

Chromatin
Memory
Polycomb-Group Proteins
Metazoa
Leukemia
PRC1 Complex Location
Cell Proliferation
Trl protein, Drosophila
Polycomb protein, Drosophila
Genes
Paper Details
References
  • References48
  • Citations39
1234

The trithorax-group and polycomb-group chromatin modifiers: implications for disease

Current Opinion in Genetics & Development

Jun 1, 1999

Maarten Van Lohuizen

PMID: 10377289

DOI: 10.1016/s0959-437x(99)80053-7

Abstract

The chromatin structure associated transcriptional memory function by Polycomb-group and trithorax-group protein complexes integrate normal development with control of cellular proliferation. This is illustrated by recent mechanistic insights that link Polycomb repression with histone d...read more

Mentioned in this Paper

Chromatin
Memory
Polycomb-Group Proteins
Metazoa
Leukemia
Paper Details
References
  • References48
  • Citations39
1234

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