The Trojan Horse Effect: An Interdisciplinary Review and Recapitulation Model of the Correlation between Alzheimer’s Disease and Air Pollution Based on Neurobiology, Sociology of Medicine, and Eco-political Science

Preprints.org
Hyun Jee Han, Clive Shrubsole

Abstract

There has been emerging evidence that air pollution is a chronic source of neuroinflammation, which contributes to Alzheimer’s Disease (AD), an increasingly common and devastating illness in elderly populations. A report on the causal relationship between PM2.5 from air pollution and AD provided scientific explanations for the mechanisms driving air pollution-induced CNS pathology, which stimulates calls for action at the political level. This review covers the scope of recognised and novel approaches associated with AD, highlighting how neurobiology, sociology of medicine and eco-politics collaborate to generate the interdisciplinary picture of the effects of PM2.5 on this malignancy. More holistic and realistic views on the current approaches will allow this field to move forward and lead to an improvement to actionable policies.

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