The trouble with quality filtering based on relative Cramér-Rao lower bounds

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Roland Kreis

Abstract

Cramér Rao Lower Bounds (CRLB) have become the standard for expression of uncertainties in quantitative MR spectroscopy. If properly interpreted as a lower threshold of the error associated with model fitting, and if the limits of its estimation are respected, CRLB are certainly a very valuable tool to give an idea of minimal uncertainties in magnetic resonance spectroscopy (MRS), although other sources of error may be larger. Unfortunately, it has also become standard practice to use relative CRLB expressed as a percentage of the presently estimated area or concentration value as unsupervised exclusion criterion for bad quality spectra. It is shown that such quality filtering with widely used threshold levels of 20% to 50% CRLB readily causes bias in the estimated mean concentrations of cohort data, leading to wrong or missed statistical findings--and if applied rigorously--to the failure of using MRS as a clinical instrument to diagnose disease characterized by low levels of metabolites. Instead, absolute CRLB in comparison to those of the normal group or CRLB in relation to normal metabolite levels may be more useful as quality criteria.

References

Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Jun 19, 2001·NMR in Biomedicine·S CavassilaD Graveron-Demilly
Jul 11, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ivan TkácRolf Gruetter
Nov 22, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A TisellP Lundberg
Feb 27, 2014·Radiology·Gülin OzUNKNOWN MRS Consensus Group

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Citations

Apr 14, 2016·NMR in Biomedicine·Nuno Pedrosa de BarrosJohannes Slotboom
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Katrin H PrellerFranz X Vollenweider
May 22, 2016·The International Journal of Neuropsychopharmacology·Márcio Gerhardt Soeiro-de-SouzaMaria Concepción Garcia Otaduy
Sep 1, 2016·NMR in Biomedicine·Andreas HockAnke Henning
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Meng LiMartin Walter
Nov 1, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Faezeh Sanaei NezhadStephen R Williams
Dec 16, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jochen BauerPatricia Ohrmann
Dec 23, 2016·Brain : a Journal of Neurology·Ahmad Seif KanaanKirsten Müller-Vahl
Jul 31, 2016·Journal of Magnetic Resonance Imaging : JMRI·Jack Knight-ScottXiaodong Zhong
Apr 13, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jennifer K FerrisLara A Boyd
Mar 1, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lucian A B PurvisChristopher T Rodgers
Aug 16, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ioannis-Angelos GiapitzakisAnke Henning
Nov 11, 2017·Neuro-oncology·Francesca BranzoliMalgorzata Marjanska
Oct 11, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sreenath P KyathanahallyRoland Kreis
Jan 19, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrik O WyssAnke Henning
Jan 16, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ioannis-Angelos GiapitzakisAnke Henning
Dec 22, 2017·The European Journal of Neuroscience·Tiffany BellAnastasia Christakou
Aug 18, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Miguel Martínez-MaestroHarald E Möller
Sep 12, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jean-Marie Bonny, Guilhem Pagès
Oct 18, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ioannis-Angelos GiapitzakisAnke Henning
Nov 30, 2018·NMR in Biomedicine·S Andrea WijtenburgGwenn S Smith
Jan 22, 2019·NMR in Biomedicine·Elvisha DhamalaJamie Near
Jan 30, 2019·Radiology·Patrik O WyssAnke Henning
Mar 29, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin WilsonFranklyn A Howe
Nov 22, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jilly NaaijenDavid J Lythgoe
Nov 14, 2019·Human Brain Mapping·Annelies J M van NulandRick C Helmich
Jan 11, 2020·NMR in Biomedicine·Gülin ÖzUNKNOWN Experts' Working Group on Advanced Single Voxel 1H MRS
Feb 11, 2020·NMR in Biomedicine·Martin MeyerspeerUNKNOWN Experts' Working Group on 31P MR Spectroscopy of Skeletal Muscle
Oct 23, 2019·The Journal of Clinical Endocrinology and Metabolism·Petr BednaříkAmir Moheet
Mar 7, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hyeong Hun Lee, Hyeonjin Kim
May 1, 2020·NMR in Biomedicine·Andrew A MaudsleyBrian J Soher
Jun 11, 2020·Current Opinion in Neurology·Francesca Branzoli, Małgorzata Marjańska
Feb 27, 2020·Cephalalgia : an International Journal of Headache·David M NiddamShuu-Jiun Wang

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