The TRPC1 Ca2+ -permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes

The Journal of Biological Chemistry
Danielle KroutKate J Claycombe-Larson

Abstract

The transient receptor potential canonical channel-1 (TRPC1) is a Ca2+-permeable channel found in key metabolic organs and tissues, including the hypothalamus, adipose tissue, and skeletal muscle. Loss of TRPC1 may alter the regulation of cellular energy metabolism resulting in insulin resistance thereby leading to diabetes. Exercise reduces insulin resistance, but it is not known whether TRPC1 is involved in exercise-induced insulin sensitivity. The role of TRPC1 in adiposity and obesity-associated metabolic diseases has not yet been determined. Our results show that TRPC1 functions as a major Ca2+ entry channel in adipocytes. We have also shown that fat mass and fasting glucose concentrations were lower in TRPC1 KO mice that were fed a high-fat (HF) (45% fat) diet and exercised as compared with WT mice fed a HF diet and exercised. Adipocyte numbers were decreased in both subcutaneous and visceral adipose tissue of TRPC1 KO mice fed a HF diet and exercised. Finally, autophagy markers were decreased and apoptosis markers increased in TRPC1 KO mice fed a HF diet and exercised. Overall, these findings suggest that TRPC1 plays an important role in the regulation of adiposity via autophagy and apoptosis and that TRPC1 inhibits the ...Continue Reading

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Citations

Jan 9, 2019·Journal of Cellular Physiology·Peng GaoZhiming Zhu
Mar 17, 2020·Adipocyte·Mingzhu ZhaiWuping Sun
May 26, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M BishnoiS K Panchal
Sep 3, 2020·Cells·Xingjuan ChenAlexander G Obukhov
Jan 30, 2019·Scientific Reports·Baptiste RodeDavid J Beech
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Wuping SunTao Zhu
Sep 10, 2021·Annual Review of Pharmacology and Toxicology·Robin S BonPiruthivi Sukumar

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Methods Mentioned

BETA
sedation
nuclear magnetic resonance
ELISA

Software Mentioned

GraphPad Prism
ImageJ

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