The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers

Journal of Clinical Pathology
H-P HornyP Valent

Abstract

Compact tryptase-positive round cell infiltrates of the bone marrow (TROCI-BM) are very rare histopathological findings and may pose challenging problems with regard to the cell type involved (either mast cells or basophilic granulocytes) and the exact diagnosis. A selected panel of immunohistochemical markers against mast cell and basophil related antigens, including CD25, CD34, CD117/Kit, and the 2D7 antigen (which is found only in basophilic granulocytes) on a total of 410 routinely processed bone marrow biopsy specimens (including 88 cases of systemic mastocytosis (SM), 20 cases of chronic myeloid leukaemia (CML), 92 cases of myeloid neoplasms other than CML, and 210 controls with normal/reactive bone marrows). In total, 17 cases with TROCI-BM could be identified: 11 SM (including two cases of well-differentiated SM and two mast cell leukaemias; MCL), 2 myelomastocytic leukaemia (MML), 2 CML with excess of basophils (secondary basophilic leukaemia (CMLba)), and 2 tryptase positive acute myeloid leukaemia (AML). Regarding the cell types involved, TROCI-BM cells were found to express CD117/Kit in all cases of SM and MCL. In MML and tryptase postitive AML, TROCI-BM cells were found to coexpress CD34 and Kit. The basophil speci...Continue Reading

References

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Sep 16, 1998·The American Journal of Surgical Pathology·H P HornyP Valent
May 30, 2001·Leukemia Research·P ValentJ M Bennett
Mar 29, 2002·International Archives of Allergy and Immunology·Hans-Peter Horny, Peter Valent
May 29, 2002·The Hematology Journal : the Official Journal of the European Haematology Association·Peter ValentKlaus Lechner
Mar 5, 2003·Leukemia & Lymphoma·Wolfgang R SperrPeter Valent
Mar 1, 1991·The Journal of Investigative Dermatology·D D Metcalfe

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Citations

May 10, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Laura Sánchez-MuñozLuis Escribano
May 9, 2014·International Journal of Hematology·Jingchun JinYazhu Wang
Mar 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P ValentH-P Horny
Jun 30, 2012·Archives of Pathology & Laboratory Medicine·Maggie M Stoecker, Endi Wang
Nov 8, 2011·Hematology/oncology Clinics of North America·Tracy I George, Hans-Peter Horny
Jun 24, 2015·The Journal of Allergy and Clinical Immunology·Iván Álvarez-TwoseLuis Escribano
Dec 1, 2010·Surgical Pathology Clinics·Tracy I George, Hans-Peter Horny
Nov 30, 2010·Best Practice & Research. Clinical Haematology·Peter ValentHans-Peter Horny
Jul 3, 2007·Leukemia Research·Hans-Peter HornyPeter Valent
Jul 16, 2014·Clinical Lymphoma, Myeloma & Leukemia·Amy RichSergej Konoplev
Oct 22, 2013·São Paulo Medical Journal = Revista Paulista De Medicina·Alex Freire SandesEdgar Gil Rizzatti
Aug 30, 2014·Expert Review of Hematology·Peter ValentMichel Arock
Aug 19, 2009·American Journal of Clinical Pathology·Hans-Peter Horny
Aug 8, 2008·American Journal of Physiology. Renal Physiology·Pia WelkerHarm Peters
Jul 16, 2014·Expert Review of Hematology·Hans-Peter HornyPeter Valent
Jan 1, 2014·Terapevticheskiĭ arkhiv·A L MelikianT N Obukhova
Sep 12, 2020·Curēus·Youssef Khafateh, Barina Aqil
Sep 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P ValentH-P Horny

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