PMID: 6412314Jan 1, 1983Paper

The TSH-response to TRH: A possible predictor of outcome to antidepressant and neuroleptic treatment

Progress in Neuro-psychopharmacology & Biological Psychiatry
G LangerG Schönbeck

Abstract

This study was designed to investigate the possible common patterns of neuroendocrine mechanisms, which may be involved in the therapeutic effects of antidepressant drugs in depressive and of neuroleptic drugs in schizophrenic patients. Sixty-three depressed women (major depressive disorder) and 21 paranoid-hallucinatory women have been studied while on antidepressant (clomipramine) or neuroleptic (haloperidol) treatment, respectively. The neuroendocrine test (TRH-test) was performed at weekly intervals. The change of TSH-response to TRH during treatment, i.e. the treatment associated normalization of a former blunted TSH-response, can tentatively be regarded as a predictor of outcome for depressive and paranoid-hallucinatory patients to their respective drug treatments. Antidepressant and neuroleptic drugs appear to involve the normalization of the TSH-response in their therapeutic effects in that proportion of patients (40%) which showed a blunted TSH-response at admission.

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Citations

Jan 1, 1989·Biological Psychiatry·S SouthwickT R Kosten
Jan 1, 1989·Psychoneuroendocrinology·J R MagliozziJ N Laubly
Aug 1, 1988·Biological Psychiatry·C M BeasleyD L Garver
Feb 12, 2004·Journal of Psychopharmacology·Kelly A GendallSue E Luty
Jun 1, 1989·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·S H Kennedy, R T Joffe

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