The TT genotype of methylenetetrahydrofolate reductase 677C>T polymorphism increases the susceptibility to pediatric ischemic stroke: meta-analysis of the 822 cases and 1,552 controls.

Molecular Biology Reports
Beata Sarecka-HujarEwa Pilarska

Abstract

The 677C>T polymorphism within methylenetetrahydrofolate reductase (MTHFR) gene is related to an elevated level of homocysteine. Thus it may be considered as a genetic risk factor in ischemic stroke. Apparently studies of this type of polymorphism in childhood stroke have shown conflicting results. We performed meta-analysis of all the data that are available in relation with MTHFR polymorphism and the risk of ischemic stroke in children. We searched PubMed (last search dated December 2010) using "MTHFR polymorphism", "ischemic stroke" "child", "children", "pediatric stroke" as keywords and reference lists of studies and reviews on the topic. Finally, 15 case-control studies corresponded to the inclusion criteria for meta-analysis. These studies involved the total number of 822 children and adolescents after ischemic stroke and 1,552 control subjects. Fixed or random effects models were used depending on the heterogeneity between the studies. The association between ischemic stroke and 677C>T polymorphism within MTHFR gene was observed in three of the studies. The pooled analysis showed that TT genotype of MTHFR gene is more common in stroke patients than in controls (p = 0.0402, odds ratio = 1.57, 95 % confidence interval 1.02...Continue Reading

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Citations

Dec 21, 2013·British Journal of Haematology·Monika StollUlrike Nowak-Göttl
Dec 3, 2014·European Journal of Medical Genetics·Siaw-Cheok Liew, Esha Das Gupta
Aug 29, 2014·American Journal of Hypertension·Eliyahu M Heifetz, Ruth Z Birk
Aug 12, 2014·Cell Biochemistry and Biophysics·Wei ZhangGuorong Bi
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Anna BalcerzykIwona Żak
Jan 8, 2020·Brain Sciences·Beata Sarecka-Hujar, Ilona Kopyta
Jun 11, 2020·World Journal of Clinical Cases·Beata Sarecka-Hujar, Ilona Kopyta
Jun 27, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Beata Sarecka-HujarAndrzej Sobczak

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Methods Mentioned

BETA
genotyping

Software Mentioned

MIX

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