The tubular hypothesis of nephron filtration and diabetic kidney disease.

Nature Reviews. Nephrology
Volker Vallon, Scott C Thomson

Abstract

Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes, and elevated GFR is a risk factor for the development of diabetic kidney disease. Hyperfiltration mainly occurs in response to signals passed from the tubule to the glomerulus: high levels of glucose in the glomerular filtrate drive increased reabsorption of glucose and sodium by the sodium-glucose cotransporters SGLT2 and SGLT1 in the proximal tubule. Passive reabsorption of chloride and water also increases. The overall capacity for proximal reabsorption is augmented by growth of the proximal tubule, which (alongside sodium-glucose cotransport) further limits urinary glucose loss. Hyperreabsorption of sodium and chloride induces tubuloglomerular feedback from the macula densa to increase GFR. In addition, sodium-glucose cotransport by SGLT1 on macula densa cells triggers the production of nitric oxide, which also contributes to glomerular hyperfiltration. Although hyperfiltration restores sodium and chloride excretion it imposes added physical stress on the filtration barrier and increases the oxygen demand to drive reabsorption. Tubular growth is associated with the development of a senescence-like molecular signature that sets the st...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S WilcoxH H Schmidt
Apr 1, 1990·Kidney International·T P HannedoucheJ P Grünfeld
Sep 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·J C MbanyaR Wilkinson
Jan 1, 1987·The Journal of Diabetic Complications·K Seyer-Hansen
Feb 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·V Vallon, H Osswald
Feb 1, 1993·The American Journal of Physiology·S B PedersenB Richelsen
Jul 1, 1997·The Journal of Laboratory and Clinical Medicine·V VallonS C Thomson
Aug 1, 1997·Clinical and Experimental Pharmacology & Physiology·W J Welch, C S Wilcox
Apr 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H J BaumgartlE Standl
Aug 5, 1999·Kidney International·G Wolf, F N Ziyadeh
Oct 19, 1999·The Journal of Clinical Investigation·S C ThomsonR C Blantz
Jul 21, 2000·The Journal of Clinical Investigation·S ThomsonV Vallon
Sep 1, 2000·American Journal of Physiology. Renal Physiology·R KomersS Anderson
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Volker VallonScott Thomson
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Holly J KramerChi-Yuan Hsu
Nov 12, 2003·Kidney & Blood Pressure Research·C BirkV Vallon
Dec 6, 2003·American Journal of Physiology. Renal Physiology·Scott C ThomsonRoland C Blantz
Dec 25, 2003·Diabetes Care·Richard J MacIsaacGeorge Jerums
Feb 1, 1951·The Journal of Clinical Investigation·S J FARBERD P EARLE
Jun 24, 2004·American Journal of Physiology. Renal Physiology·Scott C ThomsonFrancis B Gabbai
Dec 16, 2004·American Journal of Physiology. Renal Physiology·Ho Jae HanMary Taub
Apr 12, 2005·Advances in Chronic Kidney Disease·M C ThomasM E Cooper
Apr 21, 2005·Kidney International·Ruisheng LiuJeffrey L Garvin
Jul 4, 2006·Physiological Reviews·Volker VallonHartmut Osswald
Oct 5, 2006·American Journal of Physiology. Renal Physiology·Myung-Ja LeeBalakuntalam S Kasinath
Jan 11, 2007·American Journal of Physiology. Renal Physiology·Alan M WeinsteinTong Wang
Feb 23, 2007·Journal of the American Society of Nephrology : JASN·Christoph SchmidtMichael Bucher
Mar 8, 2007·Kidney International·Y RenO A Carretero
Aug 4, 2007·Kidney International. Supplement·H Noh, G L King
Aug 10, 2007·American Journal of Physiology. Renal Physiology·Swasti TiwariCarolyn A Ecelbarger

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Citations

May 1, 2020·Diabetes, Obesity & Metabolism·Marta MazzucatoAngelo Avogaro
Jun 26, 2020·Journal of Cellular and Molecular Medicine·Hui Juan ZhengWei Jing Liu
Jul 19, 2020·Journal of Clinical Medicine·Luca De NicolaRoberto Minutolo
Jul 24, 2020·Current Opinion in Nephrology and Hypertension·Jessica A Dominguez RiegTimo Rieg
Sep 24, 2020·Journal of Nephrology·Samuel Mon-Wei YuPaolo Cravedi
Oct 6, 2020·Frontiers in Physiology·Koji TakemuraReiko Inagi
Aug 15, 2020·Nature Reviews. Disease Primers·Jeffrey B KoppPaola Romagnani
Aug 14, 2020·Biological Trace Element Research·Cristhian Neftaly Sánchez-SolísSamuel Treviño
Jun 20, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takahiro Masuda, Daisuke Nagata
Aug 14, 2020·Channels·Naghmeh Hassanzadeh KhayyatOleh Pochynyuk
Sep 8, 2020·American Journal of Physiology. Renal Physiology·Akira OnishiVolker Vallon
Jul 28, 2020·American Journal of Physiology. Renal Physiology·Jin WenZheng Dong
Oct 6, 2020·American Journal of Physiology. Renal Physiology·Alexander StaruschenkoJanani Rangaswami
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Roberta CostaSilvia Dossena
Nov 17, 2020·Annual Review of Physiology·Volker Vallon, Subodh Verma
Nov 4, 2020·International Journal of Molecular Sciences·Markus PirklbauerHerbert Schramek
Feb 3, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nobuo TsuboiTakashi Yokoo
Feb 7, 2021·Nature Reviews. Nephrology·Ralph A DeFronzoAlaa S Awad
Mar 18, 2021·Inflammopharmacology·Markus Pirklbauer
Mar 27, 2021·Current Opinion in Nephrology and Hypertension·Caitlyn VlasschaertSamuel A Silver
Mar 2, 2021·American Journal of Physiology. Renal Physiology·Scott Culver Thomson, Volker Vallon
May 1, 2021·International Journal of Molecular Sciences·Giovanna LeonciniRoberto Pontremoli
Jun 3, 2021·Nature Reviews. Nephrology·Mattias Carlström
Jun 3, 2021·International Journal of Molecular Sciences·Markus PirklbauerHerbert Schramek
May 22, 2021·Free Radical Biology & Medicine·Xia-Qing WuYing-Yong Zhao
Jul 25, 2021·International Journal of Molecular Sciences·Hideyuki OkumaKyoichiro Tsuchiya
Apr 9, 2021·Clinical and Experimental Pediatrics·Hyung Eun Yim, Kee Hwan Yoo

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BETA
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