PMID: 6538199Jan 1, 1984Paper

The tumor-inhibiting effect of isomeric dichloro(diphenylethylenediamine)platinum(II) complexes

Journal of Cancer Research and Clinical Oncology
B WappesS Seeber

Abstract

Ring unsubstituted dichloro(diphenylethylenediamine)platinum(II) complexes show a dependence of their antitumor activity on the configuration and position of phenyl rings in ethylenediamine ligand. Dichloro(1,1-diphenylethylenediamine)platinum(II) (1d) and meso-dichloro(1,2-diphenylethylenediamine)-platinum(II) (meso-2d) have a weaker effect on the human breast-cancer cell line MDA-MB 231 and on rat leukemia L 5222 than (+/-)-dichloro(1,2-diphenylethylenediamine)platinum(II)((+)-2d) and its enantiomers (+)-2d and (-)-2d which cause marked and comparable inhibition of both tumors; (+/-)-2d is also active on ADJ/PC 6 plasmacytoma of the mouse and on cisplatin-, daunomycin-, and cisplatin/daunomycin-resistant Ehrlich ascites tumors of the mouse. The differences in activity of the diastereomers (+/-)-2d and meso-2d, for which distinct influences on the DNA secondary structure can be demonstrated CD spectroscopically may be explained by a steric hindrance of the drug-DNA interaction.

References

Mar 1, 1979·Chemical & Pharmaceutical Bulletin·Y KidaniS Tsukagoshi
Jan 1, 1976·Acta Haematologica·W Calvo, D Hoelzer
Jan 1, 1975·Bioinorganic Chemistry·J P Macquet, T Theophanides
Apr 26, 1969·Nature·B RosenbergV H Mansour

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Citations

Apr 1, 1988·Cancer Metastasis Reviews·P C Hydes, M J Russell
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·M JennerweinR Osieka
Dec 1, 1987·Cancer Treatment Reviews·J EngelP Hilgard

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