PMID: 2105975Feb 15, 1990Paper

The tumor necrosis factors: cachectin and lymphotoxin

Hospital Practice
B Beutler

Abstract

The extensive tissue damage associated with endotoxemia and the phenomenon of tumor necrosis are both triggered by cachectin and lymphotoxin--two leukocyte products with potentially toxic effects on virtually every organ system. Understanding the role of these cytokines in the pathogenesis of inflammation may lead to effective therapy for a wide range of diseases.

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E BeutlerB Beutler
May 20, 1989·Lancet·K J TraceyA Cerami
Jun 9, 1988·The New England Journal of Medicine·H R MichieD W Wilmore
May 16, 1988·Biochemical and Biophysical Research Communications·B BeutlerD Crawford
Feb 12, 1987·The New England Journal of Medicine·B Beutler, A Cerami
Oct 24, 1986·Science·K J TraceyJ D Albert

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Citations

May 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·D J RodriguezD E Fry
Feb 1, 1993·Anaesthesia and Intensive Care·M Malouf, A R Glanville
May 1, 1991·Journal of the American Academy of Dermatology·P E WakefieldM S Meltzer

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