PMID: 18414039Apr 17, 2008Paper

The tumor suppressor p53: cancer and aging

Cell Cycle
Zhaohui FengArnold J Levine

Abstract

Aging, like many other biological processes, is subject to regulation by genes that reside in pathways that have been conserved during evolution. The insulin/ IGF-1 pathway, mTOR pathway and p53 pathway are among those conserved pathways that impact upon longevity and aging-related diseases such as cancer. Most cancers arise in the last quarter of life span with the frequency increasing exponentially with time, and mutation accumulation in critical genes (e.g., p53) in individual cells over a lifetime is thought to be the reason. Recently, we found that the efficiency of the p53 response to stress declines significantly with age in mice, and the time of onset of this decreased p53 response correlates with the life span of mice. Given the crucial role of the p53 in tumor prevention, this decline in p53 activity at older ages in animals could contribute to the observed dramatic increases in cancer frequency, and provides a plausible explanation for the correlation between tumorigenesis and aging in addition to the accumulation of DNA mutations over lifetime. We discuss here the coordination and communication between the p53 pathway and the IGF-1-mTOR pathways, and their possible impact on cancer and longevity.

Citations

Sep 18, 2009·Nature Reviews. Cancer·Karen H Vousden, Kevin M Ryan
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zoya N DemidenkoMikhail V Blagosklonny
Jul 3, 2010·Cold Spring Harbor Perspectives in Biology·Andrei V Gudkov, Elena A Komarova
Jun 3, 2010·Cold Spring Harbor Perspectives in Biology·Vladimir A BelyiArnold J Levine
Jul 23, 2011·Genes & Cancer·Andrei V GudkovElena A Komarova
Jul 23, 2011·Genes & Cancer·Zhaohui FengRui Wu
Mar 9, 2010·Cell Division·Richa SinghYogeshwer Shukla
Mar 9, 2011·Bioinformation·Luv Kashyap
May 3, 2012·Proceedings of the American Thoracic Society·Bartolome R Celli
Feb 11, 2015·International Journal of Molecular Sciences·Al-Shwyeh Hussah AbdullahMohamed Elwathig Saeed Mirghani
Oct 26, 2011·Critical Reviews in Oncology/hematology·Nicholas PavlidisRiccardo A Audisio
Nov 3, 2009·Urologic Oncology·PierFrancesco Bassi, Emilio Sacco
Nov 3, 2009·Urologic Oncology·Shahrokh F ShariatMichael J Droller
Jan 6, 2009·Biochimica Et Biophysica Acta·Alba MinelliZoran Culig
Oct 22, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christopher D BriggsDavid P Berry
Jan 31, 2009·Journal of Cellular Biochemistry·Lin NiYoshinori Kamisaki
Mar 13, 2010·International Journal of Cancer. Journal International Du Cancer·Hongyu ZhouShile Huang
Jul 5, 2011·Reviews in Medical Virology·Pedro A Lazo, Claudio R Santos
Apr 12, 2016·Ageing Research Reviews·Divaker Choubey, Ravichandran Panchanathan
Mar 13, 2014·Inhalation Toxicology·Naema ElhosaryMerfat Oreby
Jun 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kendra AlltonMichelle Craig Barton
Apr 17, 2015·BMC Complementary and Alternative Medicine·Al-Shwyeh Hussah AbdullahMothanna Sadiq Al-Qubaisi
Mar 25, 2014·Biochimica Et Biophysica Acta·Steven Fletcher, Edward V Prochownik
Nov 5, 2011·Journal of Hepatology·Sabrina A Stratton, Michelle Craig Barton
Dec 4, 2013·Cell Cycle·Tatiana V PospelovaValery A Pospelov
Feb 28, 2014·Oncoimmunology·Mikhail V Blagosklonny
Jun 12, 2014·Frontiers in Physiology·Jörg ReichrathKlaus Roemer
Jul 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Youngzee SongPaul Schimmel

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