The tumor suppressor role of miR-4782-3p in hepatocellular carcinoma

Oncology Reports
Wentao BoAixiang Liu

Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortalities in China. Although advances have been made in treatments, the prognosis of HCC patients has not improved significantly. MicroRNAs (miRNA) play important roles in all stage of the progress of HCC. miR-4782-3p takes part in the pathogenesis of non-small cell lung cancer (NSCLC). However, the role of miR-4782-3p in HCC remains unknown. In the present study, we found that miR-4782-3p had low expression in HCC tissues. The low expression of miR-4782-3p indicated shorter survival of HCC patients. Moreover, the low expression of miR-4782-3p promoted HCC cells growth and inhibited cell apoptosis. We confirmed that USP14 was targeted by miR-4782-3p in HCC cells.

References

May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Jul 7, 2007·Molecular Cell·Andrew GrimsonDavid P Bartel
Jan 8, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anuradha BudhuXin Wei Wang
Apr 25, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yannick LadeiroJessica Zucman-Rossi
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thian-Sze WongWilliam Ignace Wei
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chiara Braconi, Tushar Patel
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Jan 6, 2009·Journal of Cellular and Molecular Medicine·Laura GramantieriMassimo Negrini
Jan 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shunsuke UraShuichi Kaneko
May 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Teng XuShi-Mei Zhuang
Jul 9, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Junfang JiXin Wei Wang
Aug 28, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bo WangSamson T Jacob
Oct 9, 2009·The New England Journal of Medicine·Junfang JiXin Wei Wang
May 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guisheng SongHolger Willenbring
Mar 31, 2011·International Journal of Biological Sciences·Cong LiuJianming Cai
Sep 13, 2011·Nature Structural & Molecular Biology·David M GarciaDavid P Bartel
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jing GaoYong-Bing Xiang
Feb 22, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ning WuQiang Li
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Bin SongCong Liu
Sep 24, 2015·Oncology Reports·Gang HuangWeiping Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Ning WuQiang Li
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Haizhou GuoZhangsuo Liu
© 2022 Meta ULC. All rights reserved