The twisted relation between Pnu and SWEET transporters

Trends in Biochemical Sciences
Michael JaehmeDirk Jan Slotboom

Abstract

The evolutionary relation between sugar and vitamin transporters from the SWEET and Pnu families is unclear. They have similar 3D structures, but differ in the topology of their secondary structure elements, and lack significant sequence similarity. Here we analyze the structures and sequences of different members of the SWEET and Pnu transporter families and propose an evolutionary pathway by which they may have diverged from a common ancestor. A 3D domain swapping event can explain the topological differences between the families, as well as the puzzling observation that a highly conserved and essential sequence motif of the SWEET family (the PQ loop) is absent from the Pnu transporters.

References

Sep 1, 1995·Trends in Biochemical Sciences·U Heinemann, M Hahn
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·M J BennettD Eisenberg
Jul 17, 1998·Current Opinion in Structural Biology·A G Murzin
Dec 10, 1998·The Journal of Endocrinology·R A AjjanA P Weetman
Dec 23, 1998·FEMS Microbiology Reviews·J S Lolkema, D J Slotboom
May 22, 2002·Protein Science : a Publication of the Protein Society·Yanshun Liu, David Eisenberg
Nov 26, 2002·Journal of Bacteriology·Oleg V KurnasovAndrei L Osterman
Nov 4, 2005·Journal of Molecular Biology·Douglas L Theobald, Deborah S Wuttke
May 30, 2009·Science·Xiang GaoYigong Shi
Jan 7, 2010·Nature Structural & Molecular Biology·Douglas L Theobald, Christopher Miller
May 12, 2010·Nucleic Acids Research·Liisa Holm, Päivi Rosenström
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Raquel RuivoBruno Gasnier
May 26, 2012·Science·Sébastien HerzigJean-Claude Martinou
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Adrien JézégouBruno Gasnier
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stephen G BrohawnRoderick MacKinnon
Mar 20, 2013·Molecular Aspects of Medicine·Ernest M Wright
Aug 29, 2013·The FEBS Journal·Daniel C YeeMilton H Saier
Sep 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yuan Hu XuanWolf B Frommer
Oct 1, 2013·Molecular Biology and Evolution·Kristine A MackinDouglas L Theobald
May 20, 2014·Biochimica Et Biophysica Acta·Michael Jaehme, Dirk Jan Slotboom
Oct 8, 2014·Nature Structural & Molecular Biology·Michael JaehmeDirk Jan Slotboom
Oct 20, 2014·Nature Structural & Molecular Biology·Ines A EhrnstorferRaimund Dutzler
Jan 20, 2015·Nature Communications·Yongchan LeeOsamu Nureki
May 20, 2015·Current Opinion in Plant Biology·Joon-Seob EomWolf B Frommer

❮ Previous
Next ❯

Citations

Jan 11, 2016·Trends in Biochemical Sciences·Liang Feng, Wolf B Frommer
Dec 23, 2015·Trends in Biochemical Sciences·Michael JaehmeDirk Jan Slotboom
Jun 23, 2015·Annual Review of Biophysics·Lucy R Forrest
Jan 31, 2018·Nature Structural & Molecular Biology·Yunpeng Zhou, John H Bushweller
Mar 20, 2020·Journal of Molecular Evolution·Philippe YoukharibacheRavinder Abrol

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Transport Proteins

Bacterial transport proteins facilitate active and passive transport of small molecules and solutes across the bacterial membrane. Here is the latest research.

Bacterial Protein Structures (ASM)

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

Bacterial Protein Structures

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

Bacterial Transport Proteins (ASM)

Bacterial transport proteins facilitate active and passive transport of small molecules and solutes across the bacterial membrane. Here is the latest research.

Related Papers

Lancet
S B Matthews, A K Campbell
British Dental Journal
C A Yeung
© 2022 Meta ULC. All rights reserved