The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma

PloS One
Damien AmbrosettiNathalie M Mazure

Abstract

Clear-cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. Although ccRCC is characterized by common recurrent genetic abnormalities, including inactivation of the von Hippel-Lindau (vhl) tumor suppressor gene resulting in stabilization of hypoxia-inducible factors (HIFs), the tumor aggressiveness and outcome of ccRCC is variable. New biomarkers are thus required to improve ccRCC diagnosis, prognosis and therapeutic options. This work aims to investigate the expression of HIF and proteins involved in metabolism and pH regulation. Their correlation to histoprognostic parameters and survival was analyzed. ccRCC of 45 patients were analyzed. HIF-1α, HIF-2α, HAF, GLUT1, MCT1, MCT4, CAIX and CAXII expression was assessed by immunohistochemistry in a semi-quantitative and qualitative manner. The GLUT1, MCT1, MCT4, CAIX and CAXII mRNA levels were analyzed in an independent cohort of 43 patients. A significant correlation was observed between increased GLUT1, MCT1, CAXII protein expression and a high Fuhrman grade in ccRCC patients. Moreover, while HIF-1α, HIF-2α and HAF expression was heterogenous within tumors, we observed and confirmed that HIF-2α co-localized with HAF. We confirmed, in an independent cohort, ...Continue Reading

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Citations

Jun 7, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Sarah R VerhoeffCarla M L van Herpen
Nov 23, 2018·Cell Death and Differentiation·Hyun Jik LeeHo Jae Han
Dec 22, 2019·International Journal of Cancer. Journal International Du Cancer·Kanchustambham VijayalakshmiJames D Brooks
Jun 13, 2018·Nature Reviews. Cancer·Robert J GilliesRobert A Gatenby
Apr 8, 2020·Frontiers in Oncology·Fátima BaltazarSara Granja
Jan 16, 2021·The Journal of Biological Chemistry·Huabo WangEdward V Prochownik
Jan 19, 2020·Trends in Cancer·Shawn McGuirkJulie St-Pierre

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Datasets Mentioned

BETA
AB95957
AB53654

Software Mentioned

CAIX

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