The two sides of a lipid-protein story

Biophysics Reviews
Luis G Mansor BassoAntonio J Costa-Filho

Abstract

Protein-membrane interactions play essential roles in a variety of cell functions such as signaling, membrane trafficking, and transport. Membrane-recruited cytosolic proteins that interact transiently and interfacially with lipid bilayers perform several of those functions. Experimental techniques capable of probing changes on the structural dynamics of this weak association are surprisingly limited. Among such techniques, electron spin resonance (ESR) has the enormous advantage of providing valuable local information from both membrane and protein perspectives by using intrinsic paramagnetic probes in metalloproteins or by attaching nitroxide spin labels to proteins and lipids. In this review, we discuss the power of ESR to unravel relevant structural and functional details of lipid-peripheral membrane protein interactions with special emphasis on local changes of specific regions of the protein and/or the lipids. First, we show how ESR can be used to investigate the direct interaction between a protein and a particular lipid, illustrating the case of lipid binding into a hydrophobic pocket of chlorocatechol 1,2-dioxygenase, a non-heme iron enzyme responsible for catabolism of aromatic compounds that are industrially released...Continue Reading

References

Jan 15, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Harris
Nov 20, 1985·Journal of Molecular Biology·J M SowadskiH W Wyckoff
Sep 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·W L Hubbell, H M McConnell
Jul 15, 1971·European Journal of Biochemistry·J Seelig, W Hasselbach
Jan 27, 1971·Journal of the American Chemical Society·W L Hubbell, H M McConnell
Jan 1, 1982·Biophysical Journal·D MarshM Esmann
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C AltenbachW L Hubbell
Feb 1, 1996·Journal of Molecular Graphics·W HumphreyK Schulten
Sep 1, 1996·Progress in Lipid Research·J F Glatz, G J van der Vusse
Jun 20, 1998·Biochimica Et Biophysica Acta·N R Coe, D A Bernlohr
Nov 18, 1998·Current Opinion in Structural Biology·W L HubbellM A Lietzow
Aug 17, 1999·Current Opinion in Structural Biology·H Brockman
Jun 17, 2000·Trends in Endocrinology and Metabolism : TEM·A V Hertzel, D A Bernlohr
Aug 31, 2000·Nature Structural Biology·W L HubbellC Altenbach
Mar 17, 2001·Science·P P BorbatJ H Freed
Jul 4, 2001·The Journal of Biological Chemistry·W L SmithS Ferguson-Miller
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·D Marsh
Jan 12, 2002·Current Opinion in Structural Biology·A Arora, L K Tamm
May 16, 2002·The Journal of Biological Chemistry·David E SaslowskyJ Michael Edwardson
Jun 19, 2002·Trends in Biochemical Sciences·Linda Columbus, Wayne L Hubbell
Sep 12, 2002·Cellular and Molecular Life Sciences : CMLS·A W Zimmerman, J H Veerkamp
Jan 7, 2003·Molecular Membrane Biology·Félix M Goñi
Apr 30, 2003·Biophysical Journal·Antonio J Costa-FilhoJack H Freed
Apr 3, 2004·The Journal of Biological Chemistry·Marta FerraroniFabrizio Briganti
Jun 9, 2004·Journal of Magnetic Resonance·G JeschkeA Godt
Mar 3, 2005·Biosensors & Bioelectronics·Xuezhong DuDavid Britt
May 5, 2005·Annual Review of Biophysics and Biomolecular Structure·Wonhwa Cho, Robert V Stahelin
Apr 18, 2006·Biochimica Et Biophysica Acta·James H Hurley
Apr 14, 2007·Physical Chemistry Chemical Physics : PCCP·Gunnar Jeschke, Yevhen Polyhach
May 12, 2007·Biochimica Et Biophysica Acta·Larissa A Munishkina, Anthony L Fink

❮ Previous
Next ❯

Citations

Jan 10, 2018·Biotechnology and Applied Biochemistry·Alessandro Finazzi-Agrò
Nov 29, 2016·Scientific Reports·Luis G M BassoAntonio J Costa-Filho
Apr 25, 2018·Biomolecules·Emeline TanguyNicolas Vitale
May 17, 2017·Biophysics Reviews·Cris Dos Remedios
Dec 31, 2019·Biochimica Et Biophysica Acta. Biomembranes·Ana P FelizattiRicardo DeMarco
Nov 18, 2017·The Journal of Physical Chemistry. B·Eduardo F VicenteEduardo M Cilli
Mar 25, 2017·Biochimica Et Biophysica Acta. Biomembranes·Ernanni D VieiraAntonio J Costa-Filho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved