PMID: 11604092Oct 18, 2001Paper

The two-stage clonal expansion model as an example of a biologically based model of radiation-induced cancer

Radiation Research
W F Heidenreich, H G Paretzke

Abstract

A model with two stages and clonal expansion (TSCE) is reviewed as a prototype for biologically based models of cancer development. Applications of the TSCE model to data sets for animals and humans for particle radiation (alpha particles) are presented. The results suggest that the radiation not only influences the initiating mutation, but may also act as a promoter. A possible mechanism for the promoting action is described. The consequences of these results for the shapes of the radiation dose-response curves at low doses and dose rates are discussed.

References

Jun 1, 1990·Risk Analysis : an Official Publication of the Society for Risk Analysis·S H Moolgavkar, G Luebeck
Sep 1, 1988·Risk Analysis : an Official Publication of the Society for Risk Analysis·S H MoolgavkarD J Venzon
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Jun 1, 1981·Journal of the National Cancer Institute·S H Moolgavkar, A G Knudson
May 1, 1996·Radiation and Environmental Biophysics·W F Heidenreich
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·I P TomlinsonW F Bodmer
Apr 24, 1997·Nature·K W Kinzler, B Vogelstein
Jun 1, 1997·Risk Analysis : an Official Publication of the Society for Risk Analysis·W F HeidenreichS H Moolgavkar
Feb 27, 1998·Frontiers in Bioscience : a Journal and Virtual Library·J E Trosko, R J Ruch
May 16, 2001·Radiation Research·W F HeidenreichH G Paretzke
Mar 1, 1953·British Journal of Cancer·C O NORDLING
Mar 1, 1954·British Journal of Cancer·P ARMITAGE, R DOLL

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Citations

May 3, 2005·Radiation and Environmental Biophysics·W F HeidenreichM Rosemann
Nov 30, 2010·Radiation Protection Dosimetry·I ShuryakD J Brenner
Aug 28, 2009·Radiation Research·Hatim FakirRainer K Sachs
Nov 12, 2016·Progress in Biophysics and Molecular Biology·Josh HillerJames Keesling
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·E Georg Luebeck, William D Hazelton

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