The Two-Way Association of Periodontal Infection with Systemic Disorders: An Overview

Mediators of Inflammation
Ravinder NagpalYuichi Izumi

Abstract

Oral cavity that harbors diverse bacterial populations could also act as a site of origin for spread of pathogenic microorganisms to different body sites, particularly in immunocompromised hosts, patients, the elderly, or the underprivileged. A number of recent publications have advocated that patients with periodontal diseases are more susceptible to metabolic endotoxemia, inflammation, obesity, type 2 diabetes, and other related systemic complications, concluding that periodontal diseases could be a potential contributing risk factor for a wide array of clinically important systemic diseases. However, despite a significant increase in the prevalence of periodontal infections and systemic diseases in the past few decades, the fundamental biological mechanisms of connection between these ailments are still not fully explicated. Consequently, the mechanisms by which this bidirectional damage occurs are being explored with a concentric vision to develop strategies that could prevent or control the complications of these ailments. This paper attempts to summarize and hypothesize the diverse mechanisms that hint to a certain connection between the two prevalent chronic situations.

References

Mar 25, 1989·BMJ : British Medical Journal·K J MattilaM J Jokinen
Mar 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K J MattilaJ K Huttunen
Mar 13, 1993·BMJ : British Medical Journal·F DeStefanoC M Russell
Oct 1, 1996·Journal of Periodontology·S OffenbacherJ Beck
Oct 1, 1996·Journal of Periodontology·J BeckS Offenbacher
Mar 26, 1998·Dysphagia·S E LangmoreW J Loesche
Sep 2, 1998·Annals of Periodontology·S G Grossi, R J Genco
Sep 2, 1998·Annals of Periodontology·M C Herzberg, M W Weyer
Aug 10, 1999·Journal of Periodontology·F A Scannapieco
Dec 1, 1999·Infectious Disease Clinics of North America·J B Epstein, A W Chow
Oct 12, 2000·Clinical Microbiology Reviews·X LiI Olsen
Oct 12, 2000·British Journal of Cancer·R TalaminiS Franceschi
Nov 4, 2000·Journal of Periodontology·V I HaraszthyR J Genco
Mar 15, 2001·Journal of Periodontal Research·P P HujoelM A Listgarten
Jul 5, 2001·British Journal of Cancer·L F GarroteS Franceschi
Nov 21, 2001·Cancer Causes & Control : CCC·C C AbnetS M Dawsey
Apr 10, 2002·Journal of Clinical Periodontology·K BuhlinB Klinge
Nov 16, 2002·Lancet·Michael M Slattery, John J Morrison
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kanami ItohNaoyuki Takahashi
Jun 21, 2003·The American Journal of Clinical Nutrition·Rachael Z Stolzenberg-SolomonDemetrius Albanes
Sep 23, 2003·Stroke; a Journal of Cerebral Circulation·Perttu J Lindsberg, Armin J Grau
Sep 25, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Pirkko J PussinenSirkka Asikainen
Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vincent QuagliarelloMary Tinetti
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Catalin S BuhimschiCarl P Weiner
May 24, 2005·Clinical Oral Investigations·Andreea C DidilescuCristian Didilescu
Jul 23, 2005·Scandinavian Journal of Gastroenterology·Christian C AbnetPhilip R Taylor
Nov 8, 2005·Archives of Gerontology and Geriatrics·Shu AbeKatsuji Okuda
Nov 10, 2005·Journal of Periodontology·Robert J GencoYoji Murayama
Nov 10, 2005·Journal of Periodontology·James D Beck, Steven Offenbacher
Jan 18, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·X XiongS Offenbacher
Feb 3, 2006·International Journal of Dental Hygiene·N YoshidaM Komaki
Mar 4, 2006·Microbes and Infection·Emil KozarovDennis Lopatin
Apr 11, 2006·American Journal of Respiratory and Critical Care Medicine·Mirelle KoemanMarc J M Bonten
Aug 12, 2006·Journal of Clinical Periodontology·Lone FornerPalle Holmstrup
Jan 9, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·M Klebanoff, K Searle
Jan 18, 2007·Journal of the National Cancer Institute·Dominique S MichaudCharles S Fuchs
Mar 9, 2007·Journal of Perinatal Medicine·Christopher PretoriusRonald F Lamont
Apr 25, 2007·Journal of Clinical Periodontology·B V Karthikeyan, A R Pradeep
May 4, 2007·Periodontology 2000·Bryan S Michalowicz, Robert Durand

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Citations

Apr 6, 2016·Frontiers in Psychology·Alexandrina L Dumitrescu
Jul 4, 2016·The American Journal of Cardiology·Gorm Mørk HansenPeter Riis Hansen
Jul 13, 2016·Mediators of Inflammation·P C Carvalho-FilhoS C Trindade
Mar 10, 2017·Current Medical Research and Opinion·Maria Luisa MartelliFrancesco Martelli
Jan 31, 2019·International Dental Journal
Apr 9, 2019·Journal of Oral Rehabilitation·Ragda Abdalla-AslanGalit Almoznino
Feb 14, 2019·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Silvia Helena de Carvalho Sales-PeresElinton Adami Chaim
Sep 14, 2019·Infectious Agents and Cancer·Xiao-Bo LiuQiang Tong
Jun 19, 2020·TheScientificWorldJournal·Muhammad NazirKhalid Almas
Jul 26, 2019·Journal of Dental Research·W ChenM K Kang
Sep 18, 2020·Journal of Clinical Periodontology·Naveed SadiqM Mahmud Khan
Oct 31, 2020·Clinical and Experimental Dental Research·Harriet LarvinJianhua Wu
Jan 13, 2021·Journal of Clinical Medicine·Prescilla MartinonFlorence Carrouel
Mar 12, 2021·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Carla Fabiana TenaniFábio Luiz Mialhe

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