The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation

Brain Research
G Jean HarryMineyoshi Aoyama

Abstract

Alterations in inflammatory process, neuronal death, and glia response have been observed under manipulation of interleukin-1 (IL-1) and subsequent signaling through the type 1 IL-1 receptor (IL-1R1). To investigate the influence of IL-1R1 activation in the pathophysiology of a chemical-induced injury to the murine hippocampus, we examined the level and pattern of neuronal death and neuroinflammation in male weanling mice exposed to trimethyltin hydroxide (2.0 mg TMT/kg, i.p.). Dentate granule cell death occurred at 6 h post-TMT as detected by active caspase 3 immunostaining and presence of lectin positive microglia. The severity of neuronal death and microglia response increased by 12-24 h with elevations in mRNA levels for TNFalpha and IL-1alpha. In IL-1R1 null (IL-1R1-/-) mice, the pattern and severity of neuronal death at 24 or 72 h post-TMT was similar as compared to wildtype (WT) mice. In both groups, mRNA levels for TNFalpha and MIP-1alpha were elevated, no significant change was seen in either IL-1alpha or IL-1beta, and the early activation of microglia, including their ability to progress to a phagocytic phenotype, was maintained. Compared to WT mice, IL-1R1-/- mice displayed a limited glial fibrillary acidic protein (...Continue Reading

References

Feb 1, 1992·Journal of Neurochemistry·D E BrennemanI Gozes
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Jun 9, 1995·The Journal of Biological Chemistry·S A GreenfederG Ju
Dec 1, 1994·Immunology Today·F ColottaA Mantovani
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T OhtsukiJ M Hallenbeck
May 8, 1997·Biochemical and Biophysical Research Communications·S A LoddickN J Rothwell
Mar 1, 2000·Journal of Neuroimmunology·O TouzaniN Rothwell
Apr 8, 2000·Neuroimmunomodulation·S HuC C Chao
Jan 4, 2001·Trends in Neurosciences·N J Rothwell, G N Luheshi
Oct 5, 2001·Nature Reviews. Neuroscience·S M Allan, N J Rothwell
Dec 18, 2001·Journal of Neuroscience Research·G D JahnkeG J Harry
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Nov 6, 2002·Journal of Neuroimmunology·Ingo BechmannFrauke Zipp
Feb 14, 2003·Neuroimmunomodulation·Xiaoling C MaChristopher P Phelps
Apr 23, 2003·Brain, Behavior, and Immunity·Nancy Rothwell
Jun 5, 2003·Neurotoxicology·G Jean Harry, Christian Lefebvre d'Hellencourt
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anirban BasuSteven W Levison
Jul 22, 2005·Nature Reviews. Immunology·Stuart M AllanNancy J Rothwell
Dec 17, 2005·Glia·Ralph AndreEmmanuel Pinteaux

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Citations

Jun 5, 2010·Neurotoxicity Research·Christopher A McPhersonG Jean Harry
Mar 8, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elena PompiliLorenzo Fumagalli
Sep 19, 2008·Expert Opinion on Drug Metabolism & Toxicology·Gaylia Jean Harry, Andrew D Kraft
Mar 19, 2011·Neurochemistry International·Maria Concetta GelosoFabrizio Michetti
Mar 26, 2016·Journal of Neuroinflammation·Avinash ParimisettyChristian Lefebvre d'Hellencourt
Sep 7, 2016·International Journal of Molecular Sciences·Sandeep Vasant MoreDong-Kug Choi

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