PMID: 9435233Jan 22, 1998Paper

The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

Proceedings of the National Academy of Sciences of the United States of America
M GrellP Scheurich

Abstract

Tumor necrosis factor (TNF) can induce a variety of cellular responses at low picomolar concentrations. This is in apparent conflict with the published dissociation constants for TNF binding to TNF receptors in the order of 100-500 pM. To elucidate the mechanisms underlying the outstanding cellular sensitivity to TNF, we determined the binding characteristics of TNF to both human TNF receptors at 37 degrees C. Calculation of the dissociation constant (Kd) from the association and dissociation rate constants determined at 37 degrees C revealed a remarkable high affinity for TNF binding to the 60-kDa TNF type 1 receptor (TNF-R1; Kd = 1.9 x 10(-11) M) and a significantly lower affinity for the 80-kDa TNF type 2 receptor (TNF-R2; Kd = 4.2 x 10(-10) M). The high affinity determined for TNF-R1 is mainly caused by the marked stability of ligand-receptor complexes in contrast to the transient interaction of soluble TNF with TNF-R2. These data can readily explain the predominant role of TNF-R1 in induction of cellular responses by soluble TNF and suggest the stability of the TNF-TNF receptor complexes as a rationale for their differential signaling capability. In accordance with this reasoning, the lower signaling capability of homotrim...Continue Reading

References

May 1, 1992·Immunology Today·L A Tartaglia, D V Goeddel
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M BrockhausH Loetscher
Jan 6, 1989·Journal of Immunological Methods·A MeagerJ Woolley
Oct 1, 1989·Critical Care Medicine·P DamasP Franchimont
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F C KullP Cuatrecasas
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M TsujimotoJ Vilcek
Jul 15, 1986·International Journal of Cancer. Journal International Du Cancer·P ScheurichK Pfizenmaier
Jun 2, 1995·The Journal of Biological Chemistry·J H NaismithS R Sprang
Jan 1, 1995·Current Topics in Microbiology and Immunology·C F WareJ L Browning
Jan 1, 1993·Annual Review of Cell Biology·K J Tracey, A Cerami
Jun 27, 1996·The New England Journal of Medicine·F Bazzoni, B Beutler
Apr 18, 1997·The Journal of Biological Chemistry·J K PinckardR D Schreiber
Feb 28, 1962·Annals of the New York Academy of Sciences·J B KIRSNER
Mar 2, 1990·Science·S Kumar

❮ Previous
Next ❯

Citations

Jun 26, 1999·European Journal of Immunology·P SchneiderH Wajant
May 30, 2009·Inflammatory Bowel Diseases·RoseMarie Stillie, Andrew W Stadnyk
May 21, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hana Zelová, Jan Hošek
Mar 17, 2005·Rheumatology International·Tania SilvestriRiccardo Meliconi
Mar 18, 2009·Journal of Clinical Immunology·Elizabeth SapeyRobert A Stockley
Dec 31, 2003·Journal of Neuroimmunology·Kakuri M OmariKaterina Dorovini-Zis
Mar 22, 2000·Journal of Immunological Methods·N HollerP Schneider
Jan 1, 2003·Journal of Neuroimmunology·Kakuri M Omari, Katerina Dorovini-Zis
Aug 7, 2002·International Journal of Cardiology·Viviane M ConraadsChristiaan J Vrints
Mar 19, 2002·Cellular Signalling·David J MacEwan
Feb 13, 2001·The International Journal of Biochemistry & Cell Biology·H Wajant, P Scheurich
Dec 18, 2002·Cytokine & Growth Factor Reviews·Harald WajantPeter Scheurich
Sep 1, 2000·Journal of Biological Physics·C Guo, H Levine
Mar 29, 2011·Nature Nanotechnology·J L ArlettM L Roukes
Feb 28, 2002·British Journal of Pharmacology·David J MacEwan
Mar 17, 2000·Proceedings of the Society for Experimental Biology and Medicine·G Herbein, W A O'Brien
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kerstin KoerberGisa Tiegs
May 31, 2012·The Journal of Biological Chemistry·Isabell LangHarald Wajant
Mar 12, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sarah Q ToColin D Clyne
May 13, 2011·Bioinformatics·Roberto ChignolaEdoardo Milotti
Oct 11, 2013·Journal of the National Cancer Institute·John J ConnellNicola R Sibson
Sep 19, 2012·Protein Engineering, Design & Selection : PEDS·Oliver SeifertRoland E Kontermann
Sep 6, 2013·Protein Engineering, Design & Selection : PEDS·Verena BergerRoland E Kontermann
Jan 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Eugenia Guicciardi, Gregory J Gores
Oct 11, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ping HeYong Shen
Mar 24, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Petrus J W NaudéUlrich L M Eisel
Jul 4, 2009·Veterinary Clinical Pathology·Michael KotiwIan A Shiels

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.