The type I membrane protein EFF-1 is essential for developmental cell fusion
Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their plasma membranes is poorly understood. To identify animal fusogens, we performed new screens for mutations that abolish cell fusion within tissues of C. elegans throughout development. We identified the gene eff-1, which is expressed as cells acquire fusion competence and encodes a novel integral membrane protein. EFF-1 sequence motifs suggest physicochemical actions that could cause adjacent bilayers to fuse. Mutations in the extracellular domain of EFF-1 completely block epithelial cell membrane fusion without affecting other perfusion events such as cell generation, patterning, differentiation, and adhesion. Thus, EFF-1 is a key component in the mechanism of cell fusion, a process essential to normal animal development.
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Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP
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Fusogenic activity of EFF-1 is regulated via dynamic localization in fusing somatic cells of C. elegans
Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila
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The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes
The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway
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The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating
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WASP-Arp2/3-dependent actin polymerization influences fusogen localization during cell-cell fusion in Caenorhabditiselegans embryos
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Mediastinal adenopathy, lung infiltrates, and hemophagocytosis: unusual manifestation of pediatric anaplastic large cell lymphoma: report of two cases
let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury
Restriction of Cellular Plasticity of Differentiated Cells Mediated by Chromatin Modifiers, Transcription Factors and Protein Kinases
Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis
Fusogen-mediated neuron-neuron fusion disrupts neural circuit connectivity and alters animal behavior
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Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number
Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions
Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals
Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein
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