PMID: 11879640Mar 7, 2002

The type I membrane protein EFF-1 is essential for developmental cell fusion

Developmental Cell
William A MohlerBenjamin Podbilewicz

Abstract

Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their plasma membranes is poorly understood. To identify animal fusogens, we performed new screens for mutations that abolish cell fusion within tissues of C. elegans throughout development. We identified the gene eff-1, which is expressed as cells acquire fusion competence and encodes a novel integral membrane protein. EFF-1 sequence motifs suggest physicochemical actions that could cause adjacent bilayers to fuse. Mutations in the extracellular domain of EFF-1 completely block epithelial cell membrane fusion without affecting other perfusion events such as cell generation, patterning, differentiation, and adhesion. Thus, EFF-1 is a key component in the mechanism of cell fusion, a process essential to normal animal development.

References

Nov 1, 1983·Developmental Biology·J E SulstonJ N Thomson
Feb 1, 1994·Developmental Biology·Benjamin Podbilewicz, John G White
Jan 1, 1996·Annual Review of Cell and Developmental Biology·L D HernandezJ M White
Feb 29, 2000·Molecular and Biochemical Parasitology·J PlenefischR Komuniecki
Jun 29, 2000·Annual Review of Biochemistry·R Jahn, T C Südhof

Citations

Jan 25, 2011·European Biophysics Journal : EBJ·Avraham Ashkenazi, Yechiel Shai
Mar 5, 2013·Trends in Genetics : TIG·Pablo S AguilarMelissa Wong
Feb 21, 2006·Nature Methods·Sudha BallaMartin R Schiller
Jun 16, 2005·Nature Reviews. Molecular Cell Biology·Brenda M OgleJeffrey L Platt
Dec 8, 2006·Molecular Biology of the Cell·Pablo S AguilarPeter Walter
Jan 19, 2007·Molecular Biology of the Cell·Tamar GattegnoBenjamin Podbilewicz
Sep 24, 2010·Molecular Biology of the Cell·Yukinao ShibukawaYoshinao Wada
Oct 12, 2010·Molecular Biology of the Cell·Boris FichtmanDouglass J Forbes
May 8, 2010·Science·Meital Oren-SuissaBenjamin Podbilewicz
Jul 24, 2013·Annual Review of Cell and Developmental Biology·James A McNewFederica Brandizzi
Jan 10, 2008·Annual Review of Cell and Developmental Biology·Susan E Mango
Jul 30, 2009·Journal of Cell Science·Matthew D McGeeDaniel A Starr
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anindya Ghosh-RoyAndrew D Chisholm
May 29, 2014·Nature Communications·Tzviya Zeev-Ben-MordehaiKay Grünewald
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takao InoueHiroyuki Arai
Sep 15, 2012·Annual Review of Genetics·Rachid El Bejjani, Marc Hammarlund
Oct 8, 2014·The Journal of Cell Biology·Nah-Young ShinRoland Baron
Jul 9, 2014·Annual Review of Cell and Developmental Biology·Benjamin Podbilewicz
Mar 26, 2011·Science·Ori AvinoamBenjamin Podbilewicz
Aug 28, 2003·Médecine sciences : M/S·Fabienne Paumet
Feb 9, 2016·Cell Reports·Ksenia Smurova, Benjamin Podbilewicz
Jun 4, 2014·Journal of Cellular Physiology·Rabia IslamHyun-Mo Ryoo
Mar 31, 2007·FEBS Letters·Elizabeth H ChenAgnès Vignery
Sep 5, 2015·Current Opinion in Microbiology·Stephanie HerzogAndré Fleißner
May 7, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Susanne-Filiz Onel, Renate Renkawitz-Pohl
Mar 30, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Andrew D Chisholm, Tiffany I Hsiao
Mar 19, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brent NeumannMassimo A Hilliard
Dec 4, 2003·Differentiation; Research in Biological Diversity·James Castelli-Gair Hombría, Bridget Lovegrove
Feb 14, 2015·Current Opinion in Genetics & Development·Tobias Schmid, Alex Hajnal
Feb 19, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Adam J Schindler, David R Sherwood
Jul 23, 2013·Current Opinion in Neurobiology·Ian G McLachlan, Maxwell G Heiman
Aug 11, 2015·Current Biology : CB·Yan WangMichael J Galko
Apr 15, 2014·Cell·Jimena Pérez-VargasFélix A Rey
Jun 13, 2015·BMC Developmental Biology·Darren Z L MokTakao Inoue
Jun 7, 2013·Communicative & Integrative Biology·Tsukasa Oikawa, Koichi Matsuo
Apr 1, 2012·Worm·Charles Brabin, Alison Woollard
Apr 13, 2005·Current Biology : CB·Kenji Kontani, Joel H Rothman
Nov 23, 2006·Current Biology : CB·Bridget LovegroveJames Castelli-Gair Hombría
Jul 18, 2002·Current Biology : CB·Eric Witze, Joel H Rothman
Nov 19, 2003·Mechanisms of Development·H-Arno J Müller, Olaf Bossinger
Feb 16, 2010·Developmental Cell·Pilar GonzaloAlicia G Arroyo
Apr 16, 2008·Developmental Cell·Jeffrey P RasmussenJames R Priess
May 4, 2005·Developmental Cell·Kenji KontaniJoel H Rothman
Nov 5, 2005·Cell·Leonid V Chernomordik, Michael M Kozlov
Jun 5, 2003·Cancer Cell·Dominik Duelli, Yuri Lazebnik
Dec 20, 2002·Developmental Biology·Daryl D Hurd, Kenneth J Kemphues
Jan 24, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Yue LiJiejun Fu
May 15, 2016·Seminars in Cell & Developmental Biology·Meera V Sundaram, Jennifer D Cohen
Jul 21, 2016·Seminars in Cell & Developmental Biology·Fabien Soulavie, Meera V Sundaram
Jul 30, 2016·Small GTPases·Ksenia Smurova, Benjamin Podbilewicz
Aug 5, 2016·Archives of Virology·Andrei N Vzorov, Richard W Compans
Sep 3, 2004·Current Biology : CB·Gidi ShemerBenjamin Podbilewicz
Jul 5, 2016·Seminars in Cell & Developmental Biology·Rosina Giordano-SantiniMassimo A Hilliard
Feb 27, 2008·The Journal of Cell Biology·Hui JinEric Grote
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Grant M Sumida, Soichiro Yamada
Apr 18, 2014·Biology of Reproduction·Rui WangHongmei Wang
Nov 6, 2007·Trends in Cell Biology·Meital Oren-Suissa, Benjamin Podbilewicz
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jun ShiEric N Olson
Dec 20, 2017·Development·Javier M Hernández, Benjamin Podbilewicz
Jun 20, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gidi Shemer, Benjamin Podbilewicz
Dec 14, 2018·Journal of Developmental Biology·Hanna Shin, David J Reiner
Apr 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Meital Oren-Suissa, Benjamin Podbilewicz
Jul 15, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marie-Anne Félix
Nov 5, 2003·Nature Structural Biology·Heather E ParkJudith M White
Aug 7, 2007·International Journal of Hematology·Eiichi IshiiKeisei Kawa
Nov 8, 2017·Proceedings of the National Academy of Sciences of the United States of America·Atrayee BasuAnindya Ghosh-Roy
Sep 7, 2006·The Biochemical Journal·Corinne RamosLeonid V Chernomordik
Apr 21, 2005·Blood·William J GrossmanFrederick D Goldman
Mar 19, 2020·Journal of Developmental Biology·Cátia A Carvalho, Limor Broday
May 23, 2020·ELife·Ka Man Carmen ChanDaniel A Fletcher
Jan 24, 2017·Genetics·Andrew D ChisholmWilliam G Wadsworth
Aug 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rosina Giordano-SantiniMassimo A Hilliard
Apr 3, 2019·The Journal of Cell Biology·Nicolas G BrukmanLeonid V Chernomordik
Jul 12, 2008·Nature Structural & Molecular Biology·William Wickner, Randy Schekman
Apr 3, 2019·Annual Review of Neuroscience·Sharon InbergBenjamin Podbilewicz
May 13, 2018·International Journal of Molecular Sciences·Sergey A AkimovOleg V Batishchev
Mar 19, 2020·International Journal of Molecular Sciences·Yariswamy ManjunathJussuf T Kaifi
May 3, 2018·Nature Communications·Fabien SoulavieMeera V Sundaram
Sep 19, 2019·Journal of Cell Science·Ji Hoon Kim, Elizabeth H Chen
Apr 24, 2019·The Journal of Membrane Biology·Geetanjali Meher, Hirak Chakraborty

Related Concepts

eff-1
eff-1
Metazoa
Cell Fusion Procedure
Epidermis
Epithelial Cells
Neoglycoproteins
Membrane Fusion
Cell Surface Proteins
Vulva

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