The type III secretion effector NleE inhibits NF-kappaB activation.

PLoS Pathogens
Chen NadlerIlan Rosenshine

Abstract

The complex host-pathogen interplay involves the recognition of the pathogen by the host's innate immune system and countermeasures taken by the pathogen. Detection of invading bacteria by the host leads to rapid activation of the transcription factor NF-kappaB, followed by inflammation and eradication of the intruders. In response, some pathogens, including enteropathogenic Escherichia coli (EPEC), acquired means of blocking NF-kappaB activation. We show that inhibition of NF-kappaB activation by EPEC involves the injection of NleE into the host cell. Importantly, we show that NleE inhibits NF-kappaB activation by preventing activation of IKKbeta and consequently the degradation of the NF-kappaB inhibitor, IkappaB. This NleE activity is enhanced by, but is not dependent on, a second injected effector, NleB. In conclusion, this study describes two effectors, NleB and NleE, with no similarity to other known proteins, used by pathogens to manipulate NF-kappaB signaling pathways.

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Citations

Aug 8, 2014·PLoS Pathogens·Adam J Caulfield, Wyndham W Lathem
Jan 15, 2014·Acta Crystallographica. Section D, Biological Crystallography·Wenqi LiJiawei Wang
Jan 21, 2014·Cytokine & Growth Factor Reviews·Cristina GioghaElizabeth L Hartland
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Edith GouinPascale Cossart
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Nov 30, 2011·The Journal of Cell Biology·Anne Marie KrachlerKim Orth
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Dec 24, 2014·Gut Microbes·Jaclyn S Pearson, Elizabeth L Hartland
Jun 11, 2015·Future Microbiology·Javier Sanchez-Villamil, Fernando Navarro-Garcia
Apr 30, 2013·Virulence·Analía Inés Etcheverría, Nora Lía Padola
May 5, 2012·Gut Microbes·Abigail ClementsGad Frankel
Dec 22, 2014·Apoptosis : an International Journal on Programmed Cell Death·Jie LuoShan Li
Jul 23, 2016·Frontiers in Cellular and Infection Microbiology·Steven B LewisStephanie Schüller
Sep 13, 2016·Frontiers in Cellular and Infection Microbiology·Hilo YenToru Tobe
Oct 25, 2016·Frontiers in Cellular and Infection Microbiology·Javier Sanchez-VillamilFernando Navarro-Garcia
Nov 29, 2016·Annual Review of Genetics·Jaclyn S PearsonElizabeth L Hartland
May 6, 2017·Cellular Microbiology·Jaclyn S Pearson, James M Murphy
Jan 18, 2018·Infection and Immunity·Maarten F de Jong, Neal M Alto

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Methods Mentioned

BETA
ubiquitination
PCR
transfection

Software Mentioned

EPEC
Scan
Tina
Scan â R

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