The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis

Oncogene
Rodolfo IulianoAlfredo Fusco

Abstract

We recently isolated the r-PTPeta gene, which encodes a receptor-type tyrosine phosphatase protein that suppresses the neoplastic phenotype of retrovirally transformed rat thyroid cells. The human homologue gene PTPRJ/DEP-1 is deleted in various tumors. Moreover, the Gln276Pro polymorphism, located in the extracellular region of the gene, seems to play a critical role in susceptibility to some human neoplasias. Here we report the loss of heterozygosity (LOH) of PTPRJ in 11/76 (14.5%) informative thyroid tumors (including adenomas and carcinomas). We also looked for the Gln276Pro, Arg326Gln and Asp872Glu polymorphisms in exons 5, 6 and 13 of PTPRJ in 88 patients with thyroid tumors and in 54 healthy individuals. We found that the PTPRJ genotypes homozygous for the Gln276Pro and Arg326Gln polymorphisms, and the Asp872 allele were more frequent in thyroid carcinoma patients than in healthy individuals (P=0.032). In addition, PTPRJ LOH was more frequent in thyroid carcinomas of heterozygotes for Gln276Pro and Arg326Gln compared with homozygotes (P=0.006). This suggests that the presence of hemizygosity for these polymorphisms in the tumor facilitates tumor progression. These results indicate that the genotypic profile of PTPRJ affe...Continue Reading

References

Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·L FioreF Basolo
Oct 8, 1999·The Journal of Clinical Investigation·G BaldassarreG Viglietto
Apr 27, 2000·Nature Cell Biology·J L BodmerJ Tschopp
Jul 27, 2000·Molecular and Cellular Biology·G JiangT Hunter
Oct 7, 2000·European Journal of Endocrinology·M L MartelliA Fusco
Feb 13, 2001·Cancer Letters·O Gimm
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·Y KitamuraM Emi
Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Fulvio BasoloAlfredo Fusco
Jun 11, 2002·American Journal of Physiology. Cell Physiology·J E DumontC Maenhaut
Dec 12, 2002·The Journal of Biological Chemistry·Helena L PalkaNicholas K Tonks
Feb 18, 2003·Molecular and Cellular Biology·Takamune TakahashiThomas O Daniel
Apr 1, 2003·Endocrine Pathology·Giovanni Tallini
Jun 17, 2003·Carcinogenesis·Valeria MasciulloAlfredo Fusco

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Citations

Mar 25, 2006·Nature Reviews. Cancer·Arne OstmanFrank D Böhmer
Dec 24, 2010·Nature Reviews. Cancer·Sofi G JulienMichel L Tremblay
Aug 5, 2011·Molecular Biology of the Cell·James R WhitefordJohn R Couchman
Dec 7, 2007·The American Journal of Surgical Pathology·Matthias PreusserVolkmar H Hans
Jul 10, 2007·PLoS Genetics·Concetta CuozzoEnrico V Avvedimento
Sep 9, 2010·Endocrine-related Cancer·Rodolfo IulianoAlfredo Fusco
Jun 13, 2013·Biochimica Et Biophysica Acta·Caroline E Nunes-XavierRafael Pulido
Aug 2, 2012·Journal of Cell Communication and Signaling·Yiru Xu, Gary J Fisher
Aug 13, 2009·Journal of Cancer Research and Clinical Oncology·Yuichiro MitaKenji Shimizu
Mar 10, 2009·Experimental Cell Research·Richa K DaveStuart Kellie
Feb 27, 2008·The FEBS Journal·Wiljan J A J HendriksAndrew W Stoker
Dec 4, 2010·International Journal of Cancer. Journal International Du Cancer·Ramprasath VenkatachalamRoland P Kuiper
May 9, 2012·The FEBS Journal·Francesco PaduanoRodolfo Iuliano
Mar 20, 2008·The Biochemical Journal·Nobuo TsuboiTakamune Takahashi

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