The U24 protein from human herpesvirus 6 and 7 affects endocytic recycling.

Journal of Virology
Brian M Sullivan, Laurent Coscoy

Abstract

Modulation of T-cell receptor expression and signaling is essential to the survival of many viruses. The U24 protein expressed by human herpesvirus 6A, a ubiquitous human pathogen, has been previously shown to downregulate the T-cell receptor. Here, we show that U24 also mediates cell surface downregulation of a canonical early endosomal recycling receptor, the transferrin receptor, indicating that this viral protein acts by blocking early endosomal recycling. We present evidence that U24 is a C-tail-anchored protein that is dependent for its function on TRC40/Asna-1, a component of a posttranslational membrane insertion pathway. Finally, we find that U24 proteins from other roseoloviruses have a similar genetic organization and a conserved function that is dependent on a proline-rich motif. Inhibition of a basic cellular process by U24 has interesting implications not only for the pathogenicity of roseoloviruses but also for our understanding of the biology of endosomal transport.

References

Jun 1, 1991·The Journal of General Virology·K KondoK Yamanishi
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E C SchirmerN Frenkel
Nov 17, 1990·Lancet·G R KruegerN Balachandran
Jan 1, 1988·Immunological Reviews·C A JanewayK Bottomly
Jul 1, 1989·Journal of Virology·K TakahashiK Yamanishi
Nov 15, 1988·International Journal of Cancer. Journal International Du Cancer·D V AblashiR C Gallo
Apr 1, 1987·The Journal of Experimental Medicine·M S Krangel
May 1, 1988·The Journal of Experimental Medicine·P LussoR C Gallo
Sep 17, 1987·Nature·D V AblashiP D Markham
Feb 1, 1995·Immunology Today·P Lusso, R C Gallo
Jul 1, 1994·The Journal of Pediatrics·K TanakaK Yamanishi
Sep 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A McCullersR J Whitley
May 23, 1997·The Journal of Biological Chemistry·J F PresleyF R Maxfield
Dec 14, 1999·The Journal of Biological Chemistry·A A MichelsH H Kampinga
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·L Coscoy, D Ganem
Sep 6, 2001·The Journal of Cell Biology·F D BrownJ G Donaldson
Mar 26, 2002·FEBS Letters·Maria J MaciasMarius Sudol
Jul 9, 2002·Acta Neurologica Scandinavica·F G A Moore, C Wolfson
Jan 31, 2003·Annals of Neurology·Maria V Tejada-SimonJingwu Z Zhang
Jul 15, 2003·Journal of Virology·Jean-Charles GrivelPaolo Lusso
Mar 5, 2004·Biochimica Et Biophysica Acta·Anna SchinzelChristoph Borner
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alicia BatistaMiguel A Alonso
Aug 18, 2004·Biochimica Et Biophysica Acta·Christine SalaünLuke H Chamberlain
Nov 16, 2004·Journal of Medical Virology·L De BolleLieve Naesens
Dec 1, 2004·The Journal of Biological Chemistry·Ricardo MadridSerge Benichou
May 10, 2005·Experimental Cell Research·Ramiro H MassolTomas Kirchhausen
Jul 5, 2005·Science·Ken Cadwell, Laurent Coscoy
Mar 18, 2006·The Journal of Infectious Diseases·Caroline Breese HallStephen Dewhurst
Aug 29, 2006·Chemical Society Reviews·Paul B SavageAlbert Bendelac
Aug 31, 2006·Pediatric Neurology·J Gordon Millichap, John J Millichap

❮ Previous
Next ❯

Citations

Nov 12, 2015·The Journal of General Virology·Tetsuo KoshizukaTatsuo Suzutani
Oct 28, 2014·Microbiology and Immunology·Chyntia JasirwanYasuko Mori
Feb 8, 2014·Virology·Mayuko HayashiYasuko Mori
Dec 3, 2014·Current Opinion in Virology·Emily C Leibovitch, Steven Jacobson
Dec 3, 2014·Current Opinion in Virology·Amy W Hudson
Sep 17, 2014·Biochemistry·Yurou SangSuzana K Straus
Jan 5, 2017·Scientific Reports·Yurou SangSuzana K Straus
Mar 18, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yurou SangSuzana K Straus
Jun 27, 2017·Nature Reviews. Microbiology·Nancy Raab-Traub, Dirk P Dittmer
Mar 15, 2018·Scientific Reports·Tetsuo KoshizukaTatsuo Suzutani
Nov 9, 2017·Virologica Sinica·Lingzhi LiuJianhong Lu
Mar 1, 2020·The Journal of Biological Chemistry·Ariel Shepley-McTaggartRonald N Harty
Feb 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniëlle HorstEmmanuel J H J Wiertz
Jun 15, 2020·Current Hematologic Malignancy Reports·Tapan Bhavsar, Genevieve M Crane
May 7, 2021·Journal of Virology·Melissa L WhyteAmy W Hudson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.