The U5/U6 snRNA genomic repeat of Taenia solium

The Journal of Parasitology
Bernadette Jean-JosephStan Metzenberg

Abstract

The U6 and U5 snRNA (small nuclear ribonucleic acid) genes were identified in Taenia solium with the aim of characterizing their sequence and genomic structures. They are contained within a shared 1,009-nt tandem genomic repeat and present at approximately 3 copies per haploid genome. The U6 snRNA gene shares 92 and 95% sequence similarity with the U6 homologs from humans and Schistosoma mansoni, respectively. The U5 snRNA gene of T. solium is 70% similar to the human U5 sequence in the 5' stem and loop 1 domains. The U6 and U5 snRNA genes are on complementary genomic strands and separated by 458 nt at their "heads" and 306 nt at their "tails." The nucleotides upstream of the U6 gene lack a recognizable TATA box and proximal sequence elements (PSEs), and the putative gene promoter for U5 snRNA does not resemble vertebrate examples. There are short blocks of similarity between the sequences upstream of the U5 and U6 snRNA genes, and these may be sites of shared transcription factor binding at the respective RNA polymerase II and III promoters. It is possible that this unusual allied U5/U6 snRNA genomic repeat may help mediate coordinated regulation of expression of the 2 snRNAs.

References

Aug 14, 1992·Science·J A Steitz
Apr 11, 1992·Nucleic Acids Research·M KellerP Imbault
Jun 1, 1991·Molecular and Biochemical Parasitology·S BretagneR Houin
Feb 1, 1991·Molecular and Biochemical Parasitology·J P LacletteC B Shoemaker
Apr 1, 1990·Molecular and Biochemical Parasitology·A CamposJ P Laclette
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C Santiago, W F Marzluff
Sep 23, 1988·Science·A P Wolffe, D D Brown
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Jan 1, 1994·Annual Review of Genetics·H D Madhani, C Guthrie
Mar 1, 1994·Molecular and Cellular Biology·D N FrankC Guthrie
Mar 15, 1993·Biochemical and Biophysical Research Communications·J HofmannT Dingermann
Aug 2, 1996·The Journal of Biological Chemistry·M HinzA Bindereif
Dec 20, 1996·Molecular and Biochemical Parasitology·T G RobertsN Agabian
Jul 1, 1997·Molecular and Biochemical Parasitology·R E Davis
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y x XuS Michaeli
Oct 6, 1997·The EMBO Journal·A J Newman
May 15, 1998·RNA·J S SunJ L Manley
Feb 24, 2000·Biochimica Et Biophysica Acta·M N Schnare, M W Gray
Sep 7, 2000·The Journal of Biological Chemistry·K BrehmM Frosch
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·N A Stover, R E Steele
Jun 22, 2002·Molecular and Biochemical Parasitology·Klaus BrehmMatthias Frosch

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Methods Mentioned

BETA
PCR
electrophoresis
X-ray

Software Mentioned

UW
GCG Pileup

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