The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of rosiglitazone treatment

Diabetes
Raffaele MarfellaDario Giugliano

Abstract

The role of ubiquitin-proteasome system in the accelerated atherosclerotic progression of diabetic patients is unclear. We evaluated ubiquitin-proteasome activity in carotid plaques of asymptomatic diabetic and nondiabetic patients, as well as the effect of rosiglitazone, a peroxisome proliferator-activated receptor (PPAR)-gamma activator, in diabetic plaques. Plaques were obtained from 46 type 2 diabetic and 30 nondiabetic patients undergoing carotid endarterectomy. Diabetic patients received 8 mg rosiglitazone (n = 23) or placebo (n = 23) for 4 months before scheduled endarterectomy. Plaques were analyzed for macrophages (CD68), T-cells (CD3), inflammatory cells (HLA-DR), ubiquitin, proteasome 20S activity, nuclear factor (NF)-kappaB, inhibitor of kappaB (IkappaB)-beta, tumor necrosis factor (TNF)-alpha, nitrotyrosine, matrix metalloproteinase (MMP)-9, and collagen content (immunohistochemistry and enzyme-linked immunosorbent assay). Compared with nondiabetic plaques, diabetic plaques had more macrophages, T-cells, and HLA-DR+ cells (P < 0.001); more ubiquitin, proteasome 20S activity (TNF-alpha), and NF-kappaB (P < 0.001); and more markers of oxidative stress (nitrotyrosine and O2(-) production) and MMP-9 (P < 0.01), along w...Continue Reading

References

Jan 1, 1994·Annual Review of Cell Biology·U SiebenlistK Brown
Jan 1, 1996·Annual Review of Biochemistry·O CouxA L Goldberg
Jan 14, 1999·The New England Journal of Medicine·R Ross
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·T V PetrovaL J Van Eldik
Oct 12, 1999·Free Radical Research·T IshiiS Bannai
Oct 4, 2000·Nature Medicine·A HershkoA Varshavsky
Apr 30, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gi-Wook HwangAkira Naganuma
May 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·O BarbierB Staels
Dec 12, 2002·Journal of the American College of Cardiology·Joerg HerrmannAmir Lerman
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joerg HermannAmir Lerman
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Jan 21, 2004·Cardiovascular Research·Joerg HerrmannAmir Lerman
May 15, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Allen P BurkeRenu Virmani
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Priya MohantyParesh Dandona
Oct 21, 2004·JAMA : the Journal of the American Medical Association·Luigi Giusto SpagnoliDavid R Holmes

❮ Previous
Next ❯

Citations

Jan 29, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Celine S WeissStefan E Hardt
Aug 21, 2009·Basic Research in Cardiology·Jozef Leo Van HerckArnold G Herman
Aug 30, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·U JuliusI G Obrosova
Oct 10, 2009·Cardiovascular Research·Joerg HerrmannAmir Lerman
Mar 4, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Raffaele MarfellaGiuseppe Paolisso
Mar 13, 2008·Diabetes, Obesity & Metabolism·R E Buckingham, A Hanna
Nov 1, 2006·International Journal of Clinical Practice·A Barnett
Jun 6, 2009·International Journal of Clinical Practice·G Schernthaner
May 11, 2012·American Journal of Physiology. Cell Physiology·Clintoria R WilliamsC Michael Hart
Jan 31, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Dane MeredithSusan S Smyth
Nov 1, 2007·Cardiovascular Diabetology·Raffaele MarfellaGiuseppe Paolisso
Jun 19, 2013·PloS One·Deniz RendeBetul Kirdar
Feb 22, 2008·PPAR Research·Sheng Zhong DuanRichard M Mortensen
May 13, 2014·Diabetologia·Stéphane Jaisson, Philippe Gillery
Jun 19, 2013·Clinical and Experimental Medicine·Ya-Yun WangYi-Biao Wang
Mar 28, 2009·PPAR Research·Angela TesseThierry Ragot
Feb 11, 2014·Antioxidants & Redox Signaling·Nicola Wilck, Antje Ludwig
Oct 9, 2007·Current Opinion in Cardiology·Robert L Wilensky, Damir Hamamdzic
Jul 19, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jason Y KimSung-Hoon Kim
May 25, 2007·Connective Tissue Research·Paul E NormanJonathan Golledge
Aug 29, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Janaka Karalliedde, Robin E Buckingham
Nov 12, 2015·Medical Hypotheses·Veera Ganesh YerraAshutosh Kumar
Sep 22, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ashish Kumar Sharma, B P Srinivasan
Apr 21, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qiu Jing ChenWei Feng Shen
Jan 16, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Raffaele MarfellaMichele D'Amico
Jan 8, 2008·Progress in Lipid Research·Koji Nagao, Teruyoshi Yanagita
Jul 20, 2007·Progress in Lipid Research·Nikolaus Marx, Daniel Walcher
May 8, 2009·The Mount Sinai Journal of Medicine, New York·Ole-Petter R Hamnvik, Graham T McMahon
Sep 12, 2006·Cardiovascular Drug Reviews·Clara Di FilippoMichele D'Amico
Nov 9, 2007·Diabetes/metabolism Research and Reviews·Antonio Ceriello
Sep 14, 2007·The American Journal of Medicine·Burton E Sobel
Feb 5, 2008·The American Journal of Pathology·Yoichi TakamiYasufumi Kaneda
Mar 25, 2015·The Journal of Surgical Research·Monica P RodriguezMelina R Kibbe

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.