UK Biobank is a large prospective study in the UK to investigate the role of genetic factors, environmental exposures and lifestyle in the causes of major diseases of late and middle age. Extensive data and biological samples are being collected from 500,000 participants aged between 40 and 69 years. The biological samples that are collected and how they are processed and stored will have a major impact on the future scientific usefulness of the UK Biobank resource. The aim of the UK Biobank sample handling and storage protocol is to specify methods for the collection and storage of participant samples that give maximum scientific return within the available budget. Processing or storage methods that, as far as can be predicted, will preclude current or future assays have been avoided. The protocol was developed through a review of the literature on sample handling and processing, wide consultation within the academic community and peer review. Protocol development addressed which samples should be collected, how and when they should be processed and how the processed samples should be stored to ensure their long-term integrity. The recommended protocol was extensively tested in a series of validation studies. UK Biobank collec...Continue Reading
A survey of a population exposed to high concentrations of arsenic in well water in Fairbanks, Alaska
Effect of sodium ascorbate concentration on the stability of samples for determination of serum folate levels
Measuring cytokine levels in blood. Importance of anticoagulants, processing, and storage conditions
Ethical considerations in the design and execution of the National and Hispanic Health and Nutrition Examination Survey (HANES)
Evaluation of mercury in hair, blood and muscle as biomarkers for methylmercury exposure in male and female mice
The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition
'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status
Stability of plasma levels of cytokines and soluble activation markers in patients with human immunodeficiency virus infection
Short-term storage of blood samples and DNA isolation in serum separator tubes for application in epidemiological studies and clinical research
Representative sampling and sample preparation in biological environmental monitoring using spruce shoots
Effects of EDTA and Sodium Citrate on hormone measurements by fluorometric (FIA) and immunofluorometric (IFMA) methods
Analysis of the molecular quality of human tissues: an experience from the Cooperative Human Tissue Network
The quality of DNA extracted from liquid or dried blood is not adversely affected by storage at 4 degrees C for up to 24 h
Population biobanks and returning individual research results: mission impossible or new directions?
Comparison of centre and home-based health assessments: early experience from the Irish Longitudinal Study on Ageing (TILDA)
Risk prediction measures for case-cohort and nested case-control designs: an application to cardiovascular disease.
Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies.
The Nutrinet-Santé Study: a web-based prospective study on the relationship between nutrition and health and determinants of dietary patterns and nutritional status.
Reduction of systematic bias in transcriptome data from human peripheral blood mononuclear cells for transportation and biobanking
The procurement, storage, and quality assurance of frozen blood and tissue biospecimens in pathology, biorepository, and biobank settings
The use of biospecimens in population-based research: a review of the National Cancer Institute's Division of Cancer Control and Population Sciences grant portfolio
Serum is not required for ex vivo IFN-gamma ELISPOT: a collaborative study of different protocols from the European CIMT Immunoguiding Program.
Preservation of Biospecimens at Ambient Temperature: Special Focus on Nucleic Acids and Opportunities for the Biobanking Community
SRM/MRM targeted proteomics as a tool for biomarker validation and absolute quantification in human urine
A population-based cohort study on chronic obstructive pulmonary disease in Latin America: methods and preliminary results. The PLATINO Study Phase II
Progastrin-releasing peptide is a candidate marker for quality control in clinical sample processing and storage
Isotope labeled internal standards (ILIS) as a basis for quality control in clinical studies using plasma samples
Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology.
Biological safety in the storage and transport of biological specimens from patients with respiratory diseases used in research settings
Blood Clotting Disorders
Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.