The UKPDS and its global impact

Diabetic Medicine : a Journal of the British Diabetic Association
S Genuth

Abstract

Aim To review the world-wide impact of the United Kingdom Prospective Diabetes Study (UKPDS) on diabetes health care since publication of the main study results in 1998. Methods The major papers published by the UKPDS were reviewed, e-mails and faxes were sent to diabetes associations in various regions of the world seeking information on trends in HbA1c over the past decade and similar information was obtained from a major USA laboratory. Results The UKPDS extended to type 2 diabetes and brought to completion the case for linking the microvascular vascular complications of diabetes to control of blood glucose initially demonstrated by the Diabetes Control and Complications Trial (DCCT). This helped set the standard of care for diabetes to seek an HbA1c goal of at least < 7.0% with intensive glycemic treatment and formed a fundamental part of continuing medical education. This also helped stimulate new hypoglycemic drug development and the preferential use of metformin as first line therapy was supported by UKPDS results. In many areas of the world, including the United Kingdom and the USA, a national trend to lower HbA1c levels has been seen. Economic analyses have shown UKPDS intensive treatment to be cost-effective at 6028 I...Continue Reading

References

Jul 9, 1999·Diabetes/metabolism Research and Reviews·R D Leslie
Oct 16, 1999·Primary Care·S E Baldeweg, J S Yudkin
Apr 25, 2001·Diabetologia·P ClarkeUNKNOWN UKPDS Group. United Kingdom Prospective Diabetes Study
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Silvio E Inzucchi
Oct 19, 2002·BMJ : British Medical Journal·Alastair GrayUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
Mar 22, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·L M ChuangUNKNOWN Diabcare-Asia 1998 Study Group
Sep 24, 2004·Annals of Internal Medicine·Elizabeth SelvinSherita Hill Golden
Apr 19, 2005·Diabetologia·P M ClarkeUNKNOWN UKPDS 72 United Kingdom Prospective Diabetes Study
Sep 24, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·B EliassonUNKNOWN Steering Committee of the Swedish National Diabetes Register
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research
Apr 20, 2006·Diabetes Research and Clinical Practice·Masashi KobayashiUNKNOWN Japan Diabetes Clinical Data Management Study Group
May 15, 2007·Diabetes & Metabolism·B EliassonUNKNOWN Steering Committee of the Swedish National Diabetes Register (NDR)
May 17, 2007·International Journal of Clinical Practice·D Orozco-BeltránUNKNOWN Collaborative Diabetes Study Investigators
Oct 16, 2007·Diabetes Care·Thomas J HoergerJinan B Saaddine
Feb 26, 2008·QJM : Monthly Journal of the Association of Physicians·A ElisV Shalev
Apr 15, 2008·Endocrinology and Metabolism Clinics of North America·Derek Leroith

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Citations

Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
Jul 8, 2009·Diabetes Technology & Therapeutics·Victoria AlabrabaTheresa Smyth
Jul 9, 2014·Revista clínica española·M S Ruiz de Adana, F Soriguer
Jun 24, 2009·International Journal of Food Sciences and Nutrition·Goutam ThakurDérick Rousseau
Feb 10, 2016·European Journal of Internal Medicine·Robert KrysiakBoguslaw Okopien
Nov 29, 2011·Medicina clínica·Federico Soriguer, María Soledad Ruiz de Adana
Dec 8, 2009·Pediatric Clinics of North America·Gurmeet R Singh
Feb 17, 2009·Diabetes/metabolism Research and Reviews
Apr 28, 2011·Clinical Endocrinology·Leonidas H DuntasGeorg Brabant
Jul 26, 2012·ISRN Endocrinology·Lisa R SimmonsElizabeth L Chua
Mar 1, 2012·ISRN Endocrinology·Ximena Urrutia-RojasCraig Spellman
Jan 22, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Baowei ShaoFengquan Zhang

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