The Ultegra rapid platelet-function assay: comparison to standard platelet function assays in patients undergoing percutaneous coronary intervention with abciximab therapy

American Heart Journal
Guy L WheelerDavid C Sane

Abstract

Despite the proven benefit of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention, significant interpatient variability exists in antiplatelet response. Furthermore, a diminished degree of platelet inhibition is an independent predictor of adverse cardiac events, highlighting the need for accurate and precise monitoring of platelet function. Patients (n = 192) who underwent elective percutaneous coronary intervention at 4 centers were enrolled. The following 3 time points were studied: 1, baseline, before abciximab bolus administration; 2, during, within 1 hour of abciximab bolus administration; and 3, post, 24 hours after abciximab bolus administration or at the time of patient discharge, whichever occurred first. The following 3 assays were compared at all time points: Ultegra rapid platelet-function assay (Ultegra RPFA), conventional turbidometric platelet aggregometry, and receptor binding assay with [125I]-abciximab. Variability in Ultegra RPFA measurements between operators was determined with performance of the assays at the point of care and in the laboratory. A sub-study of 22 patients at 1 center was performed in which the laboratory scientist performed all 3 assays in duplicate at each time poi...Continue Reading

Citations

Jan 1, 2008·Future Cardiology·Jochem W van WerkumJurriën M Ten Berg
Jan 24, 2007·Thrombosis Research·Paul HarrisonAlan D Michelson
Oct 11, 2008·The British Journal of Surgery·K J DickinsonS Homer-Vanniasinkam
Mar 29, 2008·American Heart Journal·Patrick GladdingHarvey White
Mar 22, 2014·The Korean Journal of Internal Medicine·Yun-Kyeong ChoKwon-Bae Kim
Jun 15, 2007·International Journal of Cardiology·John LekakisDimitris Th Kremastinos
Aug 17, 2005·American Journal of Clinical Pathology·Stewart M Knoepp, Michael Laposata
Mar 29, 2003·Current Medical Research and Opinion·Gian B DanziRoberto Baglini
Mar 5, 2005·Der Anaesthesist·S A Kozek-LangeneckerUNKNOWN Task Force on Perioperative Coagulation of the Austrian Society for Anesthesiology and Intensive Care Medicine
Jul 25, 2003·Coronary Artery Disease·Steven R Steinhubl
Apr 2, 2013·Journal of Cardiovascular Translational Research·Paul W A Janssen, Jurriën M ten Berg
Aug 25, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hassan MansouritorghabehMark Roest
Apr 10, 2012·Journal of Neuroimmunology·Gulibahaer AinidingJun-ichi Kira

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