The ultra-structural organization of the elastic network in the intra- and inter-lamellar matrix of the intervertebral disc

Acta Biomaterialia
Javad TavakoliJohn J Costi

Abstract

The inter-lamellar matrix (ILM)-located between adjacent lamellae of the annulus fibrosus-consists of a complex structure of elastic fibers, while elastic fibers of the intra-lamellar region are aligned predominantly parallel to the collagen fibers. The organization of elastic fibers under low magnification, in both inter- and intra-lamellar regions, was studied by light microscopic analysis of histologically prepared samples; however, little is known about their ultrastructure. An ultrastructural visualization of elastic fibers in the inter-lamellar matrix is crucial for describing their contribution to structural integrity, as well as mechanical properties of the annulus fibrosus. The aims of this study were twofold: first, to present an ultrastructural analysis of the elastic fiber network in the ILM and intra-lamellar region, including cross section (CS) and in-plane (IP) lamellae, of the AF using Scanning Electron Microscopy (SEM) and second, to -compare the elastic fiber orientation between the ILM and intra-lamellar region. Four samples (lumbar sheep discs) from adjacent sections (30μm thickness) of anterior annulus were partially digested by a developed NaOH-sonication method for visualization of elastic fibers by SEM. ...Continue Reading

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Citations

May 24, 2020·International Journal of Molecular Sciences·Petra Cazzanelli, Karin Wuertz-Kozak
Jul 16, 2020·International Journal of Molecular Sciences·Javad TavakoliJoanne L Tipper
Nov 11, 2020·Scientific Reports·Karim KandilFahed Zaïri
Jan 17, 2021·Acta Biomaterialia·Farshid GhezelbashJohn J Costi
Apr 12, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Shambo Bhattacharya, Devendra K Dubey

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