The ultrastructural heterogeneity of potentially preneoplastic lesions in the human bronchial mucosa

Pathology, Research and Practice
S GonzalezK M Müller

Abstract

170 consecutive biopsies from the bronchial tree were subjected to ultrastructural analysis. 62 were identified as preneoplastic lesions: of these, 7 as goblet cell hyperplasia, 20 as basal cell hyperplasia, 17 as combined goblet and basal cell hyperplasia, 10 as epidermoid metaplasia, and 8 as dysplasia. The ultrastructural features of these lesions are described. According to these results, preneoplastic lesions of the human bronchial mucosa are composed of heterogeneous populations that display mixed or combined morphologic features signaling abnormal differentiation patterns at this stage. The findings are tentatively correlated with bronchial carcinoma cell heterogeneity and histogenesis.

References

Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·E M McDowellM Huang
Aug 10, 1961·The New England Journal of Medicine·O AUERBACHL GARFINKEL

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Citations

Jan 26, 2006·Der Pathologe·C Kuhnen, B U Winter
Feb 1, 1989·Pathology, Research and Practice·K OgawaT Takeda
Feb 1, 1990·Pathology, Research and Practice·A Fisseler-EckhoffK M Müller
Dec 1, 1988·Pathology, Research and Practice·K M Müller, A Fisseler-Eckhoff

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