PMID: 376753Jun 1, 1979Paper

The ultrastructural localization of IgA deposits in chronic bullous disease of childhood (CBDC)

The Journal of Investigative Dermatology
J DabrowskiM Jarzabek-Chorzelska

Abstract

A case of bullous disease in a child with linear IgA immune deposits at the basement membrane zone and with some clinical, histological, and electron microscopic characteristics both of dermatitis herpetiformis and bullous pemphigoid, is described. The bulla formed between the basal lamina and basal cell membranes as in bullous pemphigoid, but at the same time there were numerous inflammatory cells in the dermis just below the partly destroyed basal lamina and also abundant fibrin deposits in very recent bulla and in the skin, all of which is rather characteristic of dermatitis herpetiformis. Ultrastructurally, the IgA deposits were located chiefly below the lamina basalis (the dermal type) but also, though less abundantly, in the lamina lucida, very much as we have seen them to be in adult cases with linear IgA immune deposits at the basement membrane zone. The investigations have supplied further evidence showing the chronic bullous disease of childhood to be actually a counterpart of the form in adults with the same linear localization of IgA deposits.

Citations

Jan 1, 1986·International Journal of Dermatology·K V RatnamT Tan
Sep 1, 1987·The British Journal of Dermatology·B BhogalP H McKee
May 1, 1985·International Journal of Dermatology·R Hwang, O G Rodman
Sep 1, 1985·International Journal of Dermatology·E H BeutnerS Jablonska
May 1, 1987·Pediatric Dermatology·L J Roberts, R D Sontheimer
Dec 3, 1999·International Journal of Dermatology·C A Egan, J J Zone
Jun 1, 1990·Journal of Cutaneous Pathology·E WillsteedF Wojnarowska
Mar 1, 1985·Pediatric Dermatology·S K Surbrugg, W L Weston
Dec 21, 2016·The British Journal of Dermatology·J GottliebC Prost-Squarcioni
Jun 1, 1980·The British Journal of Dermatology·R R Jones, S K Goolamali
Jul 1, 1985·Pediatric Dermatology·P DeCastroS S Raimer
Jun 1, 1996·The Journal of Investigative Dermatology·J J ZoneM J Petersen

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