The ultrastructure of Descemet's membrane. III. Fuchs' dystrophy

Archives of Ophthalmology
W M BourneR J Campbell

Abstract

The ultrastructure of Descemet's membrane was studied by transmission electron microscopy in corneal buttons removed from 11 phakic eyes with Fuchs' dystrophy. Abnormalities in Descemet's membrane consistent with abnormal endothelial function early in life (prior to age 20 years) were present in all corneas. Thus, despite the relatively late clinical onset of Fuch's dystrophy, endothelial abnormalities are present quite early in life in this disease. An abnormal fibrillar layer was thicker in those corneas with greater stromal and epithelial edema, possibly indicating that this layer is formed mainly during periods of endothelial decompensation.

Citations

Jul 23, 2013·Ophthalmology·Ursula Schlötzer-SchrehardtFriedrich E Kruse
Mar 22, 2005·Cornea·Hunter K L YuenJohn D Gottsch
Aug 15, 1992·American Journal of Ophthalmology·W M Bourne, R F Brubaker
May 1, 1988·Australian and New Zealand Journal of Ophthalmology·A M BrooksW E Gillies
Aug 1, 1990·Australian and New Zealand Journal of Ophthalmology·A M BrooksW E Gillies
Sep 17, 2019·Annual Review of Vision Science·Mario MatthaeiAlbert S Jun
Jan 1, 1990·Eye·S J Tuft, D J Coster
Jan 30, 2009·Veterinary Pathology·C KafarnikR R Dubielzig
Dec 24, 2018·Clinical & Experimental Ophthalmology·Mario MatthaeiLudwig M Heindl
Jan 1, 1996·Current Eye Research·S G LevyA C McCartney
Nov 15, 2006·Cornea·Ahmed A Hidayat, Glenn C Cockerham
Jul 14, 2010·Expert Review of Ophthalmology·Allen O Eghrari, John D Gottsch
Jan 11, 2018·Vestnik oftalmologii·S V TrufanovR Z Bagh
Apr 21, 2018·Cornea·Allen O EghrariJohn D Gottsch
Jan 1, 1995·Eye·G O Naumann
Mar 7, 2003·Journal of the American Veterinary Medical Association·Tammy Miller MichauMichael G Davidson
Jul 1, 1987·Veterinary Pathology·W J Hadlow
Sep 24, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Cristina KenneyAlexander V Ljubimov
Jun 2, 2018·Stem Cells International·Mohit ParekhStefano Ferrari
Jan 1, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Graham W Lyles, Kenneth L Cohen
May 22, 2020·Progress in Retinal and Eye Research·Stephan Ong ToneUla V Jurkunas
Feb 23, 2021·Experimental Eye Research·Isabelle XuStéphanie Proulx
Dec 2, 2010·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Graham W Lyles, Kenneth L Cohen
Aug 7, 2010·American Journal of Ophthalmology·Kamran A AhmedSanjay V Patel
Dec 3, 2011·Experimental Eye Research·Karine ZanioloStéphanie Proulx

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