The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease

Mechanisms of Ageing and Development
Paula I MoreiraGeorge Perry

Abstract

Compelling evidence supports the importance of metabolic abnormalities in Alzheimer disease pathogenesis. Indeed, that oxidative mechanisms are involved in the neuropathology associated with Alzheimer disease is evidenced by the large number of metabolic signs of oxidative stress as well as by specific markers of oxidative damage. However, in the initial stages of disease development, neurons adapt to the oxidative environment through the development of compensatory responses resulting in a shift of neuronal priority from normal function to basic survival.

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S M Keyse, R M Tyrrell
Dec 1, 1988·Annals of Neurology·R N KalariaS I Harik
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N P AzariB Horwitz
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·R E DavisW D Parker
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Oct 27, 1997·Neurology·R H SwerdlowW D Parker
Sep 4, 1999·Dementia and Geriatric Cognitive Disorders·J P Blass, G E Gibson
May 20, 2000·Annals of the New York Academy of Sciences·J P BlassG E Gibson
Feb 5, 2003·Neuro-Signals·Xiongwei ZhuMark A Smith

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Citations

Nov 30, 2011·Antioxidants & Redox Signaling·Rommy von Bernhardi, Jaime Eugenín
Oct 23, 2009·Journal of Neurochemistry·Sónia C Correia, Paula I Moreira
Jun 22, 2016·Brain Pathology·Susana CardosoPaula I Moreira
Aug 29, 2013·Arquivos de neuro-psiquiatria·Marcela Augusta de Souza PinhelDorotéia Rossi Silva Souza
Jan 23, 2009·Free Radical Research·Sandra L SiedlakGeorge Perry
Apr 8, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Kimberly FerreroDianne Langford
May 14, 2017·Biological Trace Element Research·Felipe Nathanael Coelho VazJuliana Sartori Bonini
Mar 11, 2017·Environmental Geochemistry and Health·Marina M S Cabral PintoM Teresa Condesso de Melo

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