The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons.

Genetics
W ShrefflerE Wolinsky

Abstract

Two Caenorhabditis elegans genes, unc-8 and sup-40, have been newly identified, by genetic criteria, as regulating ion channel function in motorneurons. Two dominant unc-8 alleles cause motorneuron swelling similar to that of other neuronal types in dominant mutants of the deg-1 gene family, which is homologous to a mammalian gene family encoding amiloride-sensitive sodium channel subunits. As for previously identified deg-1 family members, unc-8 dominant mutations are recessively suppressed by mutations in the mec-6 gene, which probably encodes a second type of channel component. An unusual dominant mutation, sup-41 (lb125), also co-suppresses unc-8 and deg-1, suggesting the existence of yet another common component of ion channels containing unc-8 or deg-1 subunits. Dominant, transacting, intragenic suppressor mutations have been isolated for both unc-8 and deg-1, consistent with the idea that, like their mammalian homologues, the two gene products function as multimers. The sup-40 (lb130) mutation dominantly suppresses unc-8 motorneuron swelling and produces a novel swelling phenotype in hypodermal nuclei. sup-40 may encode an ion channel component or regulator that can correct the osmotic defect caused by abnormal unc-8 cha...Continue Reading

Citations

Jan 2, 2007·Seminars in Cancer Biology·Nikos Kourtis, Nektarios Tavernarakis
Sep 24, 2004·Physiological Reviews·Popi Syntichaki, Nektarios Tavernarakis
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, Martin Chalfie
Mar 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R K Herman
Nov 14, 2002·Annual Review of Genetics·Glen G Ernstrom, Martin Chalfie
Sep 3, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I Mano, M Driscoll
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J García-AñoverosD P Corey
Apr 1, 1995·Current Biology : CB·J García-AñoverosM Chalfie
Jan 1, 1997·Annual Review of Neuroscience·J Garcia-Anoveros, D P Corey
Jan 1, 1997·Annual Review of Physiology·N Tavernarakis, M Driscoll
Jun 9, 2000·Annual Review of Neuroscience·H A Lester, A Karschin
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HarbinderM Driscoll
May 14, 2016·G3 : Genes - Genomes - Genetics·Yushu ChenMartin Chalfie
Apr 23, 2004·American Journal of Physiology. Cell Physiology·M M SedenskyP G Morgan
Jul 19, 1996·Science·D P Corey, J García-Añoveros
Jan 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Manolis Vlachos, Nektarios Tavernarakis
Jun 15, 1997·Genes & Development·H C KorswagenR H Plasterk

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