The uncertainty with nanosafety: Validity and reliability of published data

Colloids and Surfaces. B, Biointerfaces
Harald F Krug

Abstract

Use and production of chemicals and new materials are always reasons for concern especially with regard to human health and the environmental impacts. Over the past few decades occupational safety is a greater focus for toxicologists and of national and international registration programs for new products. Thus, the careful investigation of the biological effects of new chemicals and materials is critical. However, the hype around "The Nanotechnology" has boosted a competition for public funds and thereby the number of publications on this "nanotoxicology" topic has exploded. For more than two decades the public discussion around the special effects of nanomaterials or nanoparticles is ongoing without a final conclusion regarding an existing issue of a "nano-specific effect". Facing the situation of a dramatic increase in the number of publications (>4400 PubMed references in 2017 alone!); the quality of the findings appears to be questionable, particularly with regard to the implementation of risk assessment for nanomaterials. Most of the published nanotoxicology studies are associated with fundamental deficiencies in the experimental design of these investigations, including 1) a lack of rigorous and adequate physicochemical ...Continue Reading

Citations

Mar 6, 2019·Nanomaterials·James D EdeJo Anne Shatkin
Aug 1, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·N González-BallesterosR Simón-Vázquez
Dec 19, 2020·Nanotoxicology·Ceyda Oksel KarakusDavid A Winkler
Aug 11, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Guibin PangLeshuai W Zhang

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