The uncoupling effect of the nonsteroidal anti-inflammatory drug nimesulide in liver mitochondria from adjuvant-induced arthritic rats

Cell Biochemistry and Function
S M Caparroz-AssefEmy L Ishii-Iwamoto

Abstract

The aim of the present study was to evaluate the changes caused by adjuvant-induced arthritis in liver mitochondria and to investigate the effects of the nonsteroidal anti-inflammatory drug nimesulide. The main alterations observed in liver mitochondria from arthritic rats were: higher rates of state IV and state III respiration with beta-hydroxybutyrate as substrate; reduced respiratory control ratio and impaired capacity for swelling dependent on beta-hydroxybutyrate oxidation. No alterations were found in the activities of NADH oxidase and ATPase. Nimesulide produced: (1) stimulation of state IV respiration; (2) decrease in the ADP/O ratio and in the respiratory control ratio; (3) stimulation of ATPase activity of intact mitochondria; (4) inhibition of swelling driven by the oxidation of beta-hydroxybutyrate; (5) induction of passive swelling due to NH(3)/NH(4)+ redistribution. The activity of NADH oxidase was insensitive to nimesulide. Mitochondria from arthritic rats showed higher sensitivity to nimesulide regarding respiratory activity. The results of this work allow us to conclude that adjuvant-induced arthritis leads to quantitative changes in some mitochondrial functions and in the sensitivity to nimesulide. Direct evi...Continue Reading

References

Aug 1, 1989·Japanese Journal of Pharmacology·Y YamaguchiM Kunitomo
Dec 1, 1987·European Journal of Clinical Investigation·R Tocco-BradleyB R Bistrian
Oct 1, 1986·Biochemical Medicine and Metabolic Biology·S Somasundaram, J Sadique
Dec 1, 1974·Archives of Biochemistry and Biophysics·A I CederbaumE Rubin
Feb 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·W A BaumgartnerM W Whitehouse
Aug 12, 1966·Biochemical and Biophysical Research Communications·M G MustafaL Packer
Feb 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·U HopferT E Thompson
Dec 30, 1981·Biochimica Et Biophysica Acta·H Terada
Dec 12, 1980·Biochimica Et Biophysica Acta·R J Schilling, R C Reitz
Jun 1, 1994·The Journal of Clinical Investigation·R RoubenoffI H Rosenberg
Mar 1, 1997·Arthritis and Rheumatism·R RoubenoffJ J Kehayias
Dec 10, 1999·Cell Biochemistry and Function·Z Fedatto JúniorA M Kelmer-Bracht
May 12, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Z FedattoA M Kelmer-Bracht
Jan 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·C M PEARSON
Jan 25, 1961·Biochemical and Biophysical Research Communications·D O VOSSM BACILA
Jun 25, 1955·Nature·B CHANCE, G R WILLIAMS
Dec 1, 1979·Plant Physiology·D W Jung, G P Brierley

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Citations

Jan 17, 2004·Chemico-biological Interactions·Clairce Luzia Salgueiro-PagadigorriaEmy L Ishii-Iwamoto
Oct 25, 2003·Toxicology and Applied Pharmacology·Urs A Boelsterli
Jul 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alan CahillPeter Sykora
Aug 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·João P MonteiroPaulo J Oliveira
Jul 26, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Urs A Boelsterli
Jun 8, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·João P MonteiroAmália S Jurado
Feb 6, 2007·Toxicology and Applied Pharmacology·Urs A Boelsterli, Priscilla L K Lim
Mar 19, 2008·Cell Biochemistry and Function·Pamelli Maria de Souza SilvaClairce Luzia Salgueiro-Pagadigorria
Oct 27, 2005·Journal of Ethnopharmacology·Janaína Naldi ZagotoNair Seiko Yamamoto
Jan 31, 2006·Free Radical Biology & Medicine·Michie M K OngUrs A Boelsterli
Sep 17, 2003·The Journal of Toxicological Sciences·Urs A Boelsterli
Feb 9, 2011·Regulatory Toxicology and Pharmacology : RTP·Anne-Marie ZuurmondJeroen Degroot
Apr 15, 2011·Metabolism: Clinical and Experimental·Monique Cristine de OliveiraClairce Luzia Salgueiro-Pagadigorria
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Fábio E MingattoAntonio C Santos

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