The underestimated role of basophils in Ph+ chronic myeloid leukaemia

European Journal of Clinical Investigation
Peter ValentMichel Arock

Abstract

Chronic myeloid leukaemia (CML) is a hematopoietic neoplasm defined by the chromosome translocation t(9;22) and the related oncogene, BCR-ABL1. In most patients, leukaemic cells can be kept under control using BCR-ABL1-targeting drugs. However, many patients relapse which remains a clinical challenge. In particular, patients with advanced (accelerated or blast phase) CML have a poor prognosis. So far, little is known about molecular and cellular interactions and features that contribute to disease progression and drug resistance in CML. One key prognostic factor at diagnosis is marked basophilia. However, although basophils are well-known multifunctional effector cells, their impact in CML remains uncertain. In this article, we discuss the potential role of basophils as active contributors to disease evolution and progression in CML. In particular, basophils serve as a unique source of inflammatory, angiogenic and fibrogenic molecules, such as vascular endothelial growth factor or hepatocyte growth factor. In addition, basophils provide vasoactive substances, like histamine as well as the cytokine-degrading enzyme dipeptidyl-peptidase IV which may promote stem cell mobilization and the extramedullary spread of stem and progenit...Continue Reading

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Citations

Dec 17, 2019·International Journal of Laboratory Hematology·Joffrey FerielFranck Geneviève
Nov 11, 2018·British Journal of Pharmacology·Noelia A MassariVanina A Medina
Feb 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Johannes J M L Hoffmann
May 30, 2021·Annales pharmaceutiques françaises·M Arock
Oct 6, 2021·Pharmacology Research & Perspectives·María de la Paz SarasolaVanina A Medina

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Methods Mentioned

BETA
flow cytometry

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