PMID: 16518275Mar 7, 2006Paper

The underestimated role of opiates in patients with suspected sphincter of Oddi dysfunction after cholecystectomy

Gastroentérologie Clinique Et Biologique
Anne Druart-BlazyRamuntxo Arotçarena

Abstract

Pain recurrence after cholecystectomy is often attributed to sphincter of Oddi dysfunction, whose diagnostic criteria and treatments remain uncertain. We performed a retrospective study to assess the possible precipitating role of opiate ingestion in this setting. The retrospective study of the files of 147 consecutive patients investigated for post-cholecystectomy syndrome by endoscopic ultrasonography and/or endoscopic retrograde cholangiography yielded 37 cases of suspected biliary-type sphincter of Oddi dysfunction. Thirteen patients (30%) with suspected sphincter of Oddi dysfunction had taken opiate-containing drugs 15 minutes to two hours (median 1 hr) before the onset of pain ("Opiate group"). When compared with the 23 patients having not taken opiates ("Non Opiate Group"), they were significantly younger (47 vs. 60 yrs), had a narrower common bile duct (5.0 vs. 7.7 mm), but had similar biochemical abnormalities and belonged to the same Milwaukee's classes, mainly class II. None of the patients in the "Opiate group" were submitted to retrograde cholangiography or endoscopic sphincterotomy vs. 52% and 39%, respectively of the patients of the "Non-Opiate Group". After a mean follow-up of 3.5 years, there were three recurre...Continue Reading

Citations

Aug 7, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Cuiping LiXiaohua Hou
Feb 13, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F ChenZ-H Li
Jun 19, 2013·Thérapie·Delphine AbadieUNKNOWN Réseau Français des Centres Régionaux de Pharmacovigilance
Aug 31, 2019·Digestive Diseases and Sciences·Juhyeun KimAbraham Hartzema
Dec 14, 2019·Laboratory Medicine·Iván González, Stephen Roper
Feb 15, 2017·Frontiers in Nutrition·Elham AfghaniStephen J Pandol
Aug 18, 2020·European Journal of Gastroenterology & Hepatology·Sanja MaticDjordjevic Natasa
May 1, 2013·Gastroenterology·Alexandre ParienteRamuntxo Arotcarena

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