The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations

Blood
Hongbo WangMichael R Verneris

Abstract

Cyclosporin A (CSA) is commonly used to prevent graft-versus-host disease. The influence of CSA on T-cell function has been extensively investigated; however, the effect of CSA on natural killer (NK) cells is less understood. NK cells were cultured with IL-2 and IL-15 with and without CSA for 1 week. Compared with controls, CSA-treated cultures showed fewer CD56(+)CD16(+)KIR(+) NK cells and a reciprocal increase in CD56(+)CD16(-)KIR(-) cells. These changes were due mainly to a reduced proliferation of the CD56(dim) NK-cell subpopulation and a relative resistance of CD56(bright) NK cells to CSA. Following coculture with K562 targets, CSA-exposed NK cells differed from controls and lacked Ca(2+) oscillations, nuclear factor of activated T cells (NFAT) dephosphorylation, and NFAT nuclear translocation. NK cells cultured in CSA retained cytotoxicity against K562, Raji, and KIR ligand-expressing lymphoblastoid cells. NK cells cultured in CSA showed increases in NKp30 and reductions in NKp44 and NKG2D. Following IL-12 and IL-18 stimulation, CSA-treated NK cells showed more IFN-gamma-producing cells. Using in vitro NK-cell differentiation, progenitor cells gave rise to more CD56(+)KIR(-) NK cells in the presence of CSA than controls. ...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D A FrumanS J Burakoff
Jan 1, 1989·Advances in Immunology·G Trinchieri
Jun 1, 1982·Immunopharmacology·R H Yanagihara, W H Adler
Feb 1, 1981·Transplantation·M IntronaA Mantovani
Feb 1, 1995·Current Opinion in Immunology·P Scott, G Trinchieri
Apr 27, 1997·Transplantation·E PeterssonG Hedlund
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan
May 29, 1998·European Journal of Immunology·K RafiqS W Van Gool
Jan 16, 1999·Advances in Experimental Medicine and Biology·L L Lanier
Feb 9, 2000·Journal of Bioenergetics and Biomembranes·J J LemastersB Herman
Sep 8, 2000·Cytokines, Cellular & Molecular Therapy·Y G Yang
Nov 8, 2001·Trends in Immunology·M A CooperM A Caligiuri
Feb 19, 2005·Nature Reviews. Immunology·Peter Parham
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandro PoggiMaria Raffaella Zocchi
Apr 12, 2005·Nature Immunology·Tal I ArnonOfer Mandelboim
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrian F ArechigaCraig M Walsh
Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sherif S FaragUNKNOWN KIR Study Group, Center for International Blood and Marrow Transplantation Research
Aug 9, 2006·Seminars in Cancer Biology·Tal I ArnonOfer Mandelboim
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Derin B KeskinJack L Strominger
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chiara RomagnaniGuido Ferlazzo

❮ Previous
Next ❯

Citations

Jan 12, 2013·Experimental & Molecular Medicine·Eun-Jung KimSeok-Goo Cho
Mar 23, 2012·Nature Reviews. Immunology·Eric VivierLaurent Brossay
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandra Lopez-VergèsLewis L Lanier
Jan 15, 2008·Transplantation·Lu-En WaiSheri M Krams
Dec 17, 2009·Current Opinion in Oncology·Jonathan E BenjaminRobert S Negrin
Dec 19, 2009·Transplantation·Aislin C MeehanGlen P Westall
Mar 18, 2011·Journal of Innate Immunity·Jean Villard
May 27, 2011·Journal of Innate Immunity·A M TobinC O'Farrelly
Sep 22, 2010·BMC Immunology·Duangchan SuwannasaenGanjana Lertmemongkolchai
Oct 23, 2010·PloS One·Olivier MorteauChristopher A O'Callaghan
Feb 7, 2013·Journal of Cancer·Jeanne M PalmerSubramaniam Malarkannan
Mar 26, 2014·Immunological Investigations·Chunyan LiuZonghong Shao
Jan 1, 2008·Expert Review of Clinical Immunology·Suraksha AgrawalSita Naik
Nov 29, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria Shipkova, Eberhard Wieland
Dec 16, 2010·Journal of Pharmacological and Toxicological Methods·Devon D EgenolfPeter J Bugelski
Aug 20, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Karine HadayaJean Villard
May 23, 2008·The Journal of Investigative Dermatology·Amanda S BüchauRichard L Gallo
Sep 3, 2008·Cellular Immunology·Arun T Pores-FernandoAdam Zweifach
Sep 16, 2008·Best Practice & Research. Clinical Haematology·Bartosz GrzywaczMichael R Verneris
Mar 27, 2009·Journal of Cellular and Molecular Medicine·Olivier Preynat-SeauveJean Villard
Apr 24, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Johann PratschkeKatja Kotsch
Nov 27, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K HadayaJ Villard
Mar 1, 2012·Pediatric Transplantation·Betty PhamSheri M Krams
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D N EissensI Joosten
Sep 29, 2015·Annals of the New York Academy of Sciences·Umaimainthan Palendira, Alan B Rickinson
Jul 15, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Piyanuch KongtimStefan O Ciurea
Feb 15, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Inpyo ChoiKyoo-Hyung Lee
Jul 30, 2014·Biochimica Et Biophysica Acta·Jiang-Jiang QinRuiwen Zhang
Jun 23, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Saar GillRobert S Negrin
Jan 13, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Caroline Pical-IzardCyril Fauriat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.