The unexplained survival of cells in oral cancer: what is the role of p53?

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Donna A WhyteEdward J Shillitoe

Abstract

In normal oral epithelium the cells divide, mature, differentiate, and die. This sequence is not normally followed in oral cancer. Instead, the death of the cells is somehow prevented, although the pathways toward cell death in normal oral epithelium and the defects in oral cancer are not well defined. However, several components in the system have been identified, and information on their interactions is becoming available. This review summarizes the evidence for cell death being due to apoptosis and the central role of the p53 gene product in its regulation. Areas for future research are also identified.

References

Oct 1, 1992·European Journal of Cancer. Part B, Oral Oncology·N H ParkH M Cherrick
Apr 1, 1992·The Journal of Pathology·G R OgdenD P Lane
Aug 1, 1989·Carcinogenesis·R ToddD T Wong
Mar 1, 1995·Trends in Genetics : TIG·S J Korsmeyer
Apr 1, 1994·Molecular and Cellular Biology·S K ChiouE White
Nov 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R M Elledge, W H Lee
Feb 1, 1996·Journal of Cutaneous Pathology·A D BurdenR M MacKie
Dec 1, 1995·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C F RochlitzE de Kant
Dec 1, 1996·The Journal of Cell Biology·S M FrischS Sicks
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·U RodeckD L Ewert
Sep 26, 1997·Nature·K PolyakB Vogelstein
Oct 23, 1997·Biochemical and Biophysical Research Communications·Y MaruokaK Toyoshima
Oct 23, 1997·International Journal of Cancer. Journal International Du Cancer·A SekiT Kudo
Apr 22, 1999·Oral Oncology·M PartridgeJ D Langdon
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T G HuangH Y Ngan
May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
May 4, 2000·American Journal of Physiology. Cell Physiology·R LevyD M Nelson
Jul 18, 2000·Experimental Cell Research·M K KangN H Park
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·V PatelW A Yeudall
Dec 1, 2000·Nature·B VogelsteinA J Levine

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Citations

Oct 26, 2006·Journal of Molecular Histology·Mariza A MatsumotoDaniel A Ribeiro
Jul 21, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Lina S Wong, Manuela Martins-Green
Oct 21, 2014·Journal of Oral and Maxillofacial Pathology : JOMFP·Bidyut ChakrobartyDivya Uppala
Apr 14, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·E M MinicucciD M F Salvadori
Mar 23, 2010·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·A SloanM El-Sheemy
Dec 15, 2007·Pathology, Research and Practice·Daniel RibeiroMariângela E A Marques
Feb 1, 2008·Oral Oncology·Alejandra MartínezI Gina Rojas
Dec 7, 2007·Oral Oncology·E VairaktarisE Patsouris
Nov 21, 2007·Annals of Diagnostic Pathology·Chandandeep NagiDavid E Burstein
Dec 6, 2012·Toxicology Mechanisms and Methods·Renan PozziDaniel Araki Ribeiro
Jun 29, 2011·Oral Oncology·Mario Pérez-SayánsAbel García-García
Feb 28, 2014·Oncology Reports·M Pérez-SayánsA García-García
Mar 9, 2021·Expert Review of Molecular Diagnostics·Kenneth P H PritzkerDavid Mock
May 1, 2018·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Nikolaos G NikitakisAlexandra Sklavounou

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